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A review of the literature over the last 10 years indicates that urinary tract infections (UTIs) by<jats:italic>Escherichia coli<\/jats:italic>, and intra-abdominal infections (IAIs) by<jats:italic>E. coli<\/jats:italic>and<jats:italic>Klebsiella pneumoniae<\/jats:italic>, were characterized by high rates of resistance to trimethoprim\/sulfamethoxazole, quinolones, and second-generation cephalosporins, and by low levels of resistance to aminoglycosides, nitrofurantoin, and fosfomycin. In addition, preliminary data indicate an increase in IAIs by Enterobacteriaceae producing extended-spectrum<jats:italic>\u03b2<\/jats:italic>-lactamases, with reduced susceptibilities to third- and fourth-generation cephalosporins. Primary-care physicians in Latin America should recognize the public health threat associated with UTIs and IAIs by resistant Gram-negative bacteria. As the number of therapeutic options become limited, we recommend that antimicrobial prescribing be guided by infection severity, established patient risk factors for multidrug-resistant infections, acquaintance with local antimicrobial susceptibility data, and culture collection.<\/jats:p>","DOI":"10.1017\/s095026881300191x","type":"journal-article","created":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T13:40:54Z","timestamp":1375882854000},"page":"2459-2472","source":"Crossref","is-referenced-by-count":43,"title":["Resistant Gram-negative infections in the outpatient setting in Latin America"],"prefix":"10.1017","volume":"141","author":[{"given":"M. J. 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