{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:56:18Z","timestamp":1765727778233},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>This multicentre surveillance study was conducted to investigate the trends in incidence and aetiology of healthcare-associated bloodstream infections (HCA-BSIs) in Taiwan. From 2000 to 2011 a total of 56\u00a0830 HCA-BSIs were recorded at three medical centres, and coagulase-negative staphylococci (CoNS) were the most common pathogens isolated (<jats:italic>n<\/jats:italic>\u00a0=\u00a09465, 16\u00b77%), followed by <jats:italic>E. coli<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a07599, 13\u00b74%). The incidence of all HCA-BSIs in each and all hospitals significantly increased over the study period owing to the increase of aerobic Gram-positive cocci and Enterobacteriaceae by 4\u00b72% and 3\u00b76%, respectively. Non-fermenting Gram-negative bacteria, <jats:italic>Bacteroides<\/jats:italic> spp. and <jats:italic>Candida<\/jats:italic> spp. also showed an increase but there was a significant decline in the numbers of methicillin-resistant <jats:italic>S. aureus<\/jats:italic>. In conclusion, the incidence of HCA-BSIs in Taiwan is significantly increasing, especially for Enterobacteriaceae and aerobic Gram-positive cocci.<\/jats:p>","DOI":"10.1017\/s0950268813003166","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T05:36:21Z","timestamp":1387344981000},"page":"2180-2185","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["Changing aetiology of healthcare-associated bloodstream infections at three medical centres in Taiwan, 2000\u20132011"],"prefix":"10.1017","volume":"142","author":[{"given":"C. C.","family":"LAI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. H.","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. P.","family":"CHUNG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. H.","family":"SHENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. C.","family":"KO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. R.","family":"HSUEH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,12,17]]},"reference":[{"key":"S0950268813003166_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis1006"},{"key":"S0950268813003166_ref8","unstructured":"Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; Nineteenth Informational Supplement. M100-S19. CLSI, Wayne, PA, USA, 2009."},{"key":"S0950268813003166_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2009.07.028"},{"key":"S0950268813003166_ref12","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"S0950268813003166_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.05.024"},{"key":"S0950268813003166_ref13","first-page":"170","article-title":"Nosocomial bloodstream infection in Songklanagarind Hospital: outcome and factors influencing prognosis","volume":"95","author":"Hortiwakul","year":"2012","journal-title":"Journal of the Medical Association of Thailand"},{"key":"S0950268813003166_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.02.002"},{"key":"S0950268813003166_ref3","doi-asserted-by":"publisher","DOI":"10.1086\/591861"},{"key":"S0950268813003166_ref11","doi-asserted-by":"publisher","DOI":"10.1086\/606167"},{"key":"S0950268813003166_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.09.030"},{"key":"S0950268813003166_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"S0950268813003166_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.10.009"},{"key":"S0950268813003166_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1684-1182(10)60065-5"},{"key":"S0950268813003166_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-1081-1"},{"key":"S0950268813003166_ref5","first-page":"135","article-title":"Predominance of gram-negative bacilli and increasing antimicrobial resistance in nosocomial bloodstream infections at a university hospital in southern Taiwan, 1996\u20132003","volume":"39","author":"Wu","year":"2006","journal-title":"Journal of Microbiology, Immunology and Infection"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268813003166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:15:05Z","timestamp":1555892105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268813003166\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,17]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0950268813003166"],"URL":"https:\/\/doi.org\/10.1017\/s0950268813003166","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,17]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2013\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}