{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:10Z","timestamp":1786999570152,"version":"build-2736575974"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Scrub typhus is emerging and re-emerging in many areas: climate change may affect its spread. To explore the effects of meteorological factors on scrub typhus, monthly cases of scrub typhus from January 2006 to December 2012 in the Laiwu district of temperate northern China were analysed. We examined the correlations between scrub typhus and meteorological factors (and their delayed effects). We built a time-series adjusted negative binomial model to reflect the relationships between climate variables and scrub typhus cases. The key determinants of scrub typhus transmission were temperature, relative humidity and precipitation. Each 1\u00b0C increase in monthly average temperature in the previous 3 months, each 1% increase in monthly relative humidity in the previous 2 months and each 1\u00a0mm increase in monthly precipitation in the previous 3 months induced 15\u00b74%, 12\u00b76% and 0\u00b77% increases in the monthly number of cases, respectively. In conclusion, scrub typhus is affected by climate change in temperate regions.<\/jats:p>","DOI":"10.1017\/s0950268813003208","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T07:00:29Z","timestamp":1388646029000},"page":"2217-2226","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":54,"title":["Effects of meteorological factors on scrub typhus in a temperate region of China"],"prefix":"10.1017","volume":"142","author":[{"given":"L. P.","family":"YANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. J.","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"MA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. X.","family":"JIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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Laiwu city statistical information network (http:\/\/www.lwtjj.gov.cn\/tj_weblm\/pc_lm\/rk2010\/Read.Asp?Lt_NewsID=235). Accessed 6 May 2011."},{"key":"S0950268813003208_ref13","doi-asserted-by":"publisher","DOI":"10.1086\/596576"},{"key":"S0950268813003208_ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.2010.00941.x"},{"key":"S0950268813003208_ref7","first-page":"651","article-title":"Epidemiological analysis on the first outbreak of tsutsugamushi disease in Fuyang City of Anhui Province in 2008 [in Chinese]","volume":"13","author":"Wu","year":"2009","journal-title":"Chinese Journal of Disease Control and Prevention"},{"key":"S0950268813003208_ref14","first-page":"436","article-title":"Correlations between climate change-related infectious diseases and meteorological factors in Korea","volume":"43","author":"Kim","year":"2010","journal-title":"American Journal of Preventive Medicine"},{"key":"S0950268813003208_ref8","first-page":"794","article-title":"Scrub typhus in the Western Pacific region","volume":"26","author":"Silpapojakul","year":"1997","journal-title":"Annal Academic Medicine Singapore"},{"key":"S0950268813003208_ref4","first-page":"65","article-title":"Observation on clinical characteristics of tsutsugamushi disease in the epidemic focus, Hebei Province. 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What's the best R-Squared for logistic regression? Statistical Horizons (http:\/\/www.statisticalhorizons.com\/r2logistic). 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An update on vector-borne disease and research on vectors in Australia","volume":"23","author":"Russell","year":"1998","journal-title":"Journal of Vector Ecology"},{"key":"S0950268813003208_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2011.05.018"},{"key":"S0950268813003208_ref32","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.69.1110"},{"key":"S0950268813003208_ref16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7883\/yoken.JJID.2002.197","article-title":"Evaluation of national tsutsugamushi disease surveillance\u00a0\u2013\u00a0Japan, 2000","volume":"55","author":"Matsui","year":"2002","journal-title":"Japanese Journal of Infectious Diseases"},{"key":"S0950268813003208_ref18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.7883\/yoken.JJID.2008.148","article-title":"Comparative research on epidemiological aspects of tsutsugamushi disease (scrub typhus) between Korea and Japan","volume":"61","author":"Bang","year":"2008","journal-title":"Japanese Journal of Infectious Diseases"},{"key":"S0950268813003208_ref27","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.2010.43.5.436"},{"key":"S0950268813003208_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92366-2"},{"key":"S0950268813003208_ref34","first-page":"118","volume-title":"Infectious Diseases","author":"Yao","year":"2004"},{"key":"S0950268813003208_ref24","first-page":"45","volume-title":"A Human Health Perspective on Climate Change: A Report Outlining the Research Needs on the Human Health Effects of Climate Change","year":"2010"},{"key":"S0950268813003208_ref2","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.77.60"},{"key":"S0950268813003208_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07333.x"},{"key":"S0950268813003208_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jmicro\/dfn017"},{"key":"S0950268813003208_ref47","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2307\/3279442","article-title":"Correlation of chigger abundance with temperature at a hyper endemic focus of scrub typhus","volume":"62","author":"Van","year":"1976","journal-title":"Journal of Parasitology"},{"key":"S0950268813003208_ref28","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1978.11719303"},{"key":"S0950268813003208_ref36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11135-006-9018-6","article-title":"A caution regarding rules of thumb for variance inflation factors","volume":"41","author":"Robert","year":"2007","journal-title":"Quality and Quantity"},{"key":"S0950268813003208_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92367-3"},{"key":"S0950268813003208_ref11","volume-title":"Tsutsugamushi Disease: An Overview","author":"Kawamura","year":"1995"},{"key":"S0950268813003208_ref31","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-191"},{"key":"S0950268813003208_ref1","doi-asserted-by":"publisher","DOI":"10.1258\/td.2010.090508"},{"key":"S0950268813003208_ref10","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.49.425"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268813003208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T06:32:28Z","timestamp":1746081148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268813003208\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,2]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0950268813003208"],"URL":"https:\/\/doi.org\/10.1017\/s0950268813003208","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,2]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2013\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}