{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:36:53Z","timestamp":1790696213112,"version":"4.1.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T00:00:00Z","timestamp":1398297600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>This study is a part of the surveillance study on childhood diarrhoea in the Andaman and Nicobar Islands; here we report the drug resistance pattern of recent isolates of<jats:italic>Shigella<\/jats:italic>spp. (2006\u20132011) obtained as part of that study and compare it with that of<jats:italic>Shigella<\/jats:italic>isolates obtained earlier during 2000\u20132005. During 2006\u20132011, stool samples from paediatric diarrhoea patients were collected and processed for isolation and identification of<jats:italic>Shigella<\/jats:italic>spp. Susceptibility to 22 antimicrobial drugs was tested and minimum inhibitory concentrations were determined for third-generation cephalosporins, quinolones, amoxicillin-clavulanic acid combinations and gentamicin. A wide spectrum of antibiotic resistance was observed in the<jats:italic>Shigella<\/jats:italic>strains obtained during 2006\u20132011. The proportions of resistant strains showed an increase from 2000\u20132005 to 2006\u20132011 in 20\/22 antibiotics tested. The number of drug resistance patterns increased from 13 in 2000\u20132005 to 43 in 2006\u20132011. Resistance to newer generation fluoroquinolones, third-generation cephalosporins and augmentin, which was not observed during 2000\u20132005, appeared during 2006\u20132011. The frequency of resistance in<jats:italic>Shigella<\/jats:italic>isolates has increased substantially between 2000\u20132006 and 2006\u20132011, with a wide spectrum of resistance. At present, the option for antimicrobial therapy in shigellosis in Andaman is limited to a small number of drugs.<\/jats:p>","DOI":"10.1017\/s0950268814000958","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T13:01:19Z","timestamp":1398344479000},"page":"470-477","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":25,"title":["Changing patterns and widening of antibiotic resistance in<i>Shigella<\/i>spp. over a decade (2000\u20132011), Andaman Islands, India"],"prefix":"10.1017","volume":"143","author":[{"given":"D.","family":"BHATTACHARYA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"BHATTACHARYA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. S.","family":"SAYI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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Guidelines for the control of shigellosis, including epidemics due to Shigella dysenteriae type 1. Geneva: WHO, 2005 (http:\/\/whqlibdoc.who.int\/publications\/2005\/9241592330.pdf)."},{"key":"S0950268814000958_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1937-2"},{"key":"S0950268814000958_ref28","doi-asserted-by":"crossref","unstructured":"Yadav P . Countering drug resistance in the developing world: an 11 assessment across the value chain and recommendations for policy interventions. Working Paper 183. Center for Global Development, 2009 (www.cgdev.org\/content\/publications\/detail\/1422842).","DOI":"10.2139\/ssrn.1479669"},{"key":"S0950268814000958_ref12","unstructured":"Clinical and Laboratory Standards Institute. 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