{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:57:07Z","timestamp":1793642227583,"version":"4.5.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T00:00:00Z","timestamp":1398297600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A total of 180 non-duplicate carbapenem-resistant <jats:italic>Klebsiella pneumoniae<\/jats:italic> isolates were recovered from patients hospitalized between December 2010 and January 2012 at a Chinese hospital. Eight KPC-2, four NDM-1, one VIM-2, and five KPC-2 plus IMP-4 producers were identified and all were multidrug resistant due to the presence of other resistance determinants, including extended-spectrum <jats:italic>\u03b2<\/jats:italic>-lactamases (CTX-M-15, SHV-12), 16S rRNA methylases (<jats:italic>armA, rmtB<\/jats:italic>) and plasmid-mediated quinolone-resistance determinants (<jats:italic>qnr<\/jats:italic>A, B, S, <jats:italic>aac<\/jats:italic>(<jats:italic>6\u2032<\/jats:italic>)<jats:italic>-Ib-cr<\/jats:italic>). Nine <jats:italic>K. pneumoniae<\/jats:italic> clones (Kpn-A1\/ST395, Kpn-A3\/ST11, Kpn-A2\/ST134, Kpn-B\/ST263, Kpn-C\/ST37, Kpn-D\/ST39, Kpn-E\/ST1151, Kpn-F\/ST890, Kpn-G\/ST1153) were identified. <jats:italic>bla<\/jats:italic><jats:sub>KPC-2<\/jats:sub> was located on transferable ~65\u00a0kb IncL\/M (ST395, ST11, ST134, ST39) and ~100\u00a0kb IncA\/C (ST37, ST1153, ST890) plasmids, respectively. On the other hand, <jats:italic>bla<\/jats:italic><jats:sub>NDM-1<\/jats:sub> was associated with a ~70\u00a0kb IncA\/C plasmid (ST263). However, non-typable plasmids of ~40\u00a0kb containing <jats:italic>bla<\/jats:italic><jats:sub>VIM-2<\/jats:sub> were detected in the ST1151 clone. This work reports the first co-occurrence of four diverse types of carbapenemase of <jats:italic>K. pneumoniae<\/jats:italic> clones from a single hospital in China. IncA\/C, IncL\/M, and other successful plasmids may be important for the dissemination of carbapenemases, producing a complex epidemiological picture.<\/jats:p>","DOI":"10.1017\/s0950268814000995","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T15:02:10Z","timestamp":1398351730000},"page":"376-384","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":56,"title":["First description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing <i>Klebsiella pneumoniae<\/i> strains in a single Chinese teaching hospital"],"prefix":"10.1017","volume":"143","author":[{"given":"Y.","family":"LIU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-G.","family":"WAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"DENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.-W.","family":"CAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"YU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.-F.","family":"XU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,4,24]]},"reference":[{"key":"S0950268814000995_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr330"},{"key":"S0950268814000995_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr412"},{"key":"S0950268814000995_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.02.011"},{"key":"S0950268814000995_ref7","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 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