{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:06:41Z","timestamp":1762866401037},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We report the first study of macrolide resistance in respiratory tract pathogens in a Serbian paediatric population. It included 5293 <jats:italic>Streptococcus pneumoniae<\/jats:italic>, 4297 <jats:italic>Streptococcus pyogenes<\/jats:italic>, 2568 <jats:italic>Moraxella catarrhalis<\/jats:italic> and 1998 <jats:italic>Haemophilus influenzae<\/jats:italic> isolates derived from the respiratory tract and 110 invasive isolates from children aged up to 18 years during 2004\u20132009. Over the 6-year period, a significant increase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) in macrolide resistance was found in both <jats:italic>S. pneumoniae<\/jats:italic> and <jats:italic>S. pyogenes<\/jats:italic> that reached 45% and 19%, respectively, in 2009. In the same period, consumption of macrolides increased continually from 2\u00b746 to 5\u00b78 defined daily dose\/1000 inhabitants per day. The increase in macrolide resistance in <jats:italic>S. pyogenes<\/jats:italic> correlated with consumption of total macrolide and long-acting macrolides (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b7879, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b7922, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7026, respectively). A similar trend was observed in pneumoccoci, although it did not reach statistical significance. The growing problem of macrolide resistance in pneumococci and <jats:italic>S. pyogenes<\/jats:italic> in Serbia requires further vigilant surveillance.<\/jats:p>","DOI":"10.1017\/s0950268814001125","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T07:07:26Z","timestamp":1399619246000},"page":"648-652","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Trends in macrolide resistance of respiratory tract pathogens in the paediatric population in Serbia from 2004 to 2009"],"prefix":"10.1017","volume":"143","author":[{"given":"V.","family":"MIJAC","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"OPAVSKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"MARKOVIC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"GAJIC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"VASILJEVIC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"SIPETIC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"BAJCETIC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,5,9]]},"reference":[{"key":"S0950268814001125_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf809"},{"key":"S0950268814001125_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02724.x"},{"key":"S0950268814001125_ref8","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing: 14th informational supplement. CLSI document M100\u2013S12 CLSI, Wayne, PA (2004)."},{"key":"S0950268814001125_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl184"},{"key":"S0950268814001125_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02823.x"},{"key":"S0950268814001125_ref5","doi-asserted-by":"publisher","DOI":"10.1086\/383309"},{"key":"S0950268814001125_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03182.x"},{"key":"S0950268814001125_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.4.475"},{"key":"S0950268814001125_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/28.suppl_C.31"},{"key":"S0950268814001125_ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201303260503"},{"key":"S0950268814001125_ref6","first-page":"217","article-title":"Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines","volume":"16","author":"Lynch","year":"2010","journal-title":"Current Opinion in Pulmonary Medicine"},{"key":"S0950268814001125_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.2.191"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268814001125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T15:05:21Z","timestamp":1555859121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268814001125\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,9]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0950268814001125"],"URL":"https:\/\/doi.org\/10.1017\/s0950268814001125","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,9]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2014\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}