{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:53:08Z","timestamp":1790765588016,"version":"4.1.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Tuberculosis (TB) in elephants has the potential to infect humans and is an increasing public health concern. Lao PDR is one of the last countries where elephants are still used for timber extraction and where they live in close contact with their mahouts. There are 500 animals at work in the country, some interacting with wild herds. Although human TB prevalence is known to be high in Laos, studies on elephant TB had yet to be undertaken. From January to July 2012, screening was performed using the ElephantTB Stat-Pak assay on 80 elephants working around the Nam Pouy National Park in Sayaboury Province. This represents more than 18% of the total registered national working elephant population. Here we report that 36% of the elephants were seroreactive to the test. Of these, 31% had contacts with wild individuals, which suggests potential transmission of mycobacteria to the local wild herds. Clinical examination, chest X-rays, sputum microscopy and culture were performed on their 142 mahouts or owners. Despite high TB seroreactivity in elephants, no participant was smear- or culture-positive for <jats:italic>Mycobacterium tuberculosis<\/jats:italic> or <jats:italic>M. bovis<\/jats:italic>, although atypical mycobacteria were isolated from 4% of participants.<\/jats:p>","DOI":"10.1017\/s0950268814002180","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T13:22:49Z","timestamp":1409318569000},"page":"922-931","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":26,"title":["Tuberculosis in Laos, who is at risk: the mahouts or their elephants?"],"prefix":"10.1017","volume":"143","author":[{"given":"J.","family":"LASSAUSAIE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"BRET","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"BOUAPAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"CHANTHAVONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"CASTONGUAY-VANIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"QUET","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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Paris, 2000."},{"key":"S0950268814002180_ref27","first-page":"71","article-title":"A simple technique for culturing tubercle bacilli","volume":"51","author":"Kudoh","year":"1974","journal-title":"Bulletin of the World Health Organization"},{"key":"S0950268814002180_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/vr.156.6.171"},{"key":"S0950268814002180_ref29","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.106"},{"key":"S0950268814002180_ref20","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.3201\/eid0811.020302","article-title":"Human exposure following Mycobacterium tuberculosis infection of multiple animal species in a metropolitan zoo","volume":"8","author":"Granich Oh","year":"2002","journal-title":"Emerging Infectious Diseases"},{"key":"S0950268814002180_ref16","unstructured":"Abraham D , Health assessment of captive Asian elephants in India with special reference to tuberculosis. Project Elephant. Ministry of Environment and Forests. Government of India, 2008."},{"key":"S0950268814002180_ref22","doi-asserted-by":"publisher","DOI":"10.1017\/S095026881300068X"},{"key":"S0950268814002180_ref12","doi-asserted-by":"publisher","DOI":"10.3201\/eid1703.101668"},{"key":"S0950268814002180_ref34","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00133-06"},{"key":"S0950268814002180_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(00)00241-6"},{"key":"S0950268814002180_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00114-006-0144-8"},{"key":"S0950268814002180_ref33","first-page":"84","article-title":"Do water mycobacteria present any infectious risk in immunocompromised patients?","volume":"33","author":"Dailloux","year":"1992","journal-title":"Agressologie"},{"key":"S0950268814002180_ref23","unstructured":"World Health Organization. Lao People's Democratic Republic tuberculosis profile. 2012 (https:\/\/extranet.who.int\/sree\/Reports?op=Replet&name=\/WHO_HQ_Reports\/G2\/PROD\/EXT\/TBCountryProfile&ISO2=LA&outtype=html). Accessed 9 January 2014."},{"key":"S0950268814002180_ref31","doi-asserted-by":"crossref","first-page":"e615","DOI":"10.1371\/journal.pntd.0000615","article-title":"Non-tuberculous mycobacteria in TB-endemic countries: are we neglecting the danger?","volume":"4","author":"Phillips","year":"2010","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"S0950268814002180_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268813000022"},{"key":"S0950268814002180_ref1","unstructured":"World Health Organization. Global tuberculosis report 2013. World Health Organization Document (WHO\/HTM\/TB\/2013), 2013; 11, pp. 1\u2013289."},{"key":"S0950268814002180_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04388.x"},{"key":"S0950268814002180_ref21","unstructured":"Maslow J . 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