{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:05:24Z","timestamp":1768694724369,"version":"3.49.0"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:00:00Z","timestamp":1412208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The objective of this study was to estimate the relationship between serum vitamin D (VitD) status and tuberculosis (TB) infection conversion (TBIC), measured by the tuberculin skin test (TST) and an interferon-gamma release assay, the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in the contacts of pulmonary TB patients in Castellon (Spain) in a prospective cohort study from 2010 to 2012. Initially, the participants were negative to latent TB infection after a screening that included TST and QFT-GIT tests, and other examinations. A baseline determination of 25-hydroxyvitamin D [25(OH)D] was obtained by chemiluminescence immunoassay. After 8\u201310 weeks, participants were screened for a second time to determine TB infection conversion (TBIC). Poisson regression models were used in the statistical analysis. Of the 247 participants in the cohort, 198 (80\u00b72%) were screened twice and 18 (9\u00b71%) were TBIC cases. The means of VitD concentration in the TBIC cases and the non-cases were 20\u00b77\u00b111\u00b79 and 27\u00b72\u00b111\u00b74 ng\/ml (<jats:italic>P<\/jats:italic> = 0\u00b7028), respectively. Adjusted for high exposure and TB sputum acid-fast bacilli (AFB)-positive index case, higher serum VitD concentration was associated with low incidence of TBIC (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0\u00b7005), and an increase of 1 ng\/ml VitD concentration decreased the incidence of TBIC by 6% (relative risk 0\u00b794, 95% confidence interval 0\u00b790\u20130\u00b799, <jats:italic>P<\/jats:italic> = 0\u00b7015). The results suggest that sufficient VitD level could be a protective factor of TBIC.<\/jats:p>","DOI":"10.1017\/s0950268814002386","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T07:04:46Z","timestamp":1412233486000},"page":"1731-1741","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":41,"title":["Vitamin D status and incidence of tuberculosis infection conversion in contacts of pulmonary tuberculosis patients: a prospective cohort study"],"prefix":"10.1017","volume":"143","author":[{"given":"A.","family":"ARNEDO-PENA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"JUAN-CERD\u00c1N","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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