{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:43:21Z","timestamp":1788169401715,"version":"build-2803163510"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A large outbreak of enterohaemorrhagic<jats:italic>Escherichia coli<\/jats:italic>(EHEC) O111 and O157 occurred in Japan in April 2011. We conducted an unmatched case-control study and trace-back investigation to determine the source of EHEC O111 infection and risk factors for severe complications. Pulsed-field gel electrophoresis was performed to help define cases. A total of 86 individuals met the case definition. Of these, 40% experienced haemolytic uraemic syndrome (HUS), 24% acute encephalopathy, and 6% died. Illness was significantly associated with eating the raw beef dish<jats:italic>yukhoe<\/jats:italic>(odds ratio 19\u00b764, 95% confidence interval 7\u00b703\u201354\u00b783), the likely food vehicle. EHEC O111 and its closely related<jats:italic>stx-<\/jats:italic>negative variants were found in the beef. HUS occurred most frequently in individuals aged 5\u20139 years, and this age group was significantly associated with acute encephalopathy. The prevalence of HUS and acute encephalopathy was higher than in previous non-O157-related outbreaks, indicating a high risk of severe complications.<\/jats:p>","DOI":"10.1017\/s0950268814003641","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T11:12:39Z","timestamp":1421752359000},"page":"2721-2732","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":30,"title":["Epidemiological analysis of a large enterohaemorrhagic<i>Escherichia coli<\/i>O111 outbreak in Japan associated with haemolytic uraemic syndrome and acute encephalopathy"],"prefix":"10.1017","volume":"143","author":[{"given":"Y.","family":"YAHATA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"MISAKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"ISHIDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"NAGIRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"WATAHIKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"ISOBE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"TERAJIMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"IYODA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"MITOBE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"OHNISHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"SATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"TANIGUCHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"TADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"OKABE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the E. coli O111 Outbreak Investigation Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"S0950268814003641_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810000920"},{"key":"S0950268814003641_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08376-1"},{"key":"S0950268814003641_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81600-2"},{"key":"S0950268814003641_ref12","doi-asserted-by":"publisher","DOI":"10.3201\/eid1104.040739"},{"key":"S0950268814003641_ref34","doi-asserted-by":"publisher","DOI":"10.1086\/322598"},{"key":"S0950268814003641_ref24","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03469-13"},{"key":"S0950268814003641_ref21","unstructured":"National Institute of Infectious Diseases. 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