{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T08:56:11Z","timestamp":1779008171759,"version":"3.51.4"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The enteric pathogens causing diarrhoea impair children's health severely. This study retrospectively analysed 1577 pathogens isolated from inpatients and outpatients in six hospitals located in Northern (Inner Mongolia), Northeastern (Hebei), Eastern (Shanghai and Jiangsu), Southern (Hainan) and Central (Hubei) China between 2008 and 2013. Of the 1577 enteric pathogens, <jats:italic>Salmonella<\/jats:italic> presented with the highest frequency (36\u00b70%), followed by diarrhoeagenic <jats:italic>Escherichia coli<\/jats:italic> (23\u00b77%), <jats:italic>Staphylococcus aureus<\/jats:italic> (15\u00b70%), <jats:italic>Shigella<\/jats:italic> (13\u00b71%), and <jats:italic>Aeromonas<\/jats:italic> (4\u00b76%). The predominant pathogens varied in different regions of China, with <jats:italic>Salmonella<\/jats:italic> most prevalent in Shanghai and Hainan, diarrhoeagenic <jats:italic>E. coli<\/jats:italic> most prevalent in Inner Mongolia, Jiangsu and Hubei, and <jats:italic>Shigella<\/jats:italic> most prevalent in Hebei. Enteric pathogens were more frequently isolated in males (56\u00b79%) than in females (43\u00b71%). The highest proportion of all enteric pathogens was found in infants (67\u00b76%) with a peak in summer and autumn (68\u00b75%). Antimicrobial susceptibility assay demonstrated that <jats:italic>Shigella<\/jats:italic> was more resistant to ampicillin, ceftriaxone and sulfamethoxazole than <jats:italic>Salmonella<\/jats:italic>. Of the top two serotypes in <jats:italic>Salmonella<\/jats:italic>, Typhimurium was more resistant to ciprofloxacin, sulfamethoxazole and chloramphenicol than Enteritidis (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001). Meanwhile, the resistance rates of <jats:italic>Shigella flexneri<\/jats:italic> against ampicillin\/sulbactam, ciprofloxacin, and chloramphenicol were significantly higher than those of <jats:italic>Shigella sonnei<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001). Multidrug resistance was apparent in 58\u00b72% of <jats:italic>Shigella<\/jats:italic> and 45\u00b79% of <jats:italic>Salmonella<\/jats:italic>, and this phenomenon was more pronounced in <jats:italic>S. flexneri<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0950268814003756","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T01:58:31Z","timestamp":1421200711000},"page":"2512-2519","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["Distribution and antimicrobial resistance of enteric pathogens in Chinese paediatric diarrhoea: a multicentre retrospective study, 2008\u20132013"],"prefix":"10.1017","volume":"143","author":[{"given":"H.","family":"ZHANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"PAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-5656","authenticated-orcid":false,"given":"Y.","family":"TU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"FU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"PAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"SONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"JIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"XU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"REN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"ZHONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"S0950268814003756_ref22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01297-08"},{"key":"S0950268814003756_ref21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01333-10"},{"key":"S0950268814003756_ref14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4269\/ajtmh.2007.77.571","article-title":"Etiology of acute diarrhea in children and adults in Tunis, Tunisia, with emphasis on diarrheagenic Escherichia coli: prevalence, phenotyping, and molecular epidemiology","volume":"77","author":"Gallas","year":"2007","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0950268814003756_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2011.238386"},{"key":"S0950268814003756_ref23","doi-asserted-by":"publisher","DOI":"10.3201\/eid\/1706.101949"},{"key":"S0950268814003756_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.04.014"},{"key":"S0950268814003756_ref15","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2010.0827"},{"key":"S0950268814003756_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181fb6f82"},{"key":"S0950268814003756_ref12","unstructured":"WHO Collaborating Centre for Surveillance of Antimicrobial Resistance. 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