{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:52:34Z","timestamp":1791201154305,"version":"4.2.0"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"16","license":[{"start":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:00:00Z","timestamp":1432080000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Enteric viruses including norovirus and rotavirus are leading causes of gastroenteritis in Canada. However, only a small number of clinical cases are actually tested for these pathogens leading to systematic underestimation of attributed hospitalizations in administrative databases. The objective of this analysis was to estimate the number of hospitalizations due to norovirus and rotavirus in Canada. Hospitalization records for acute gastroenteritis-associated discharges at all acute-care hospitals in Canada between 2006 and 2011 were analysed. Cause-unspecified gastroenteritis hospitalizations were modelled using age-specific negative binomial models with cause-specified gastroenteritis admissions as predictors. The coefficients from the models were used to estimate the number of norovirus and rotavirus admissions. The total annual hospitalizations for rotavirus were estimated to be between 4500 and 10 000. Total annual hospitalizations for norovirus were estimated to be between 4000 and 11 000. The mean total annual cost associated with these hospitalizations was estimated to be at least $16 million for rotavirus and $21 million for norovirus (all figures in Canadian dollars). This study is the first comprehensive analysis of norovirus and rotavirus hospitalizations in Canada. These estimates provide a more complete assessment of the burden and economic costs of these pathogens to the Canadian healthcare system.<\/jats:p>","DOI":"10.1017\/s0950268815000734","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T09:45:34Z","timestamp":1432115134000},"page":"3528-3537","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":25,"title":["Estimated hospitalizations attributed to norovirus and rotavirus infection in Canada, 2006\u20132010"],"prefix":"10.1017","volume":"143","author":[{"given":"V. K.","family":"MORTON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"THOMAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"McEWEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,5,20]]},"reference":[{"key":"S0950268815000734_ref19","unstructured":"Statistics Canada, Demography Division, Demographic Estimates Section. October Population estimates, 2006\u20132010. 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Hospital morbidity database, 2006\u20132010."},{"key":"S0950268815000734_ref30","doi-asserted-by":"publisher","DOI":"10.1086\/525259"},{"key":"S0950268815000734_ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804575"},{"key":"S0950268815000734_ref10","doi-asserted-by":"publisher","DOI":"10.1086\/648440"},{"key":"S0950268815000734_ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052434"},{"key":"S0950268815000734_ref7","doi-asserted-by":"publisher","DOI":"10.1086\/499315"},{"key":"S0950268815000734_ref32","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31826a5ba1"},{"key":"S0950268815000734_ref21","unstructured":"Public Health Agency of Canada. 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Canada Communicable Disease Report July 2010, 36, ACS-4 (http:\/\/www.phac-aspc.gc.ca\/publicat\/ccdr-rmtc\/10vol36\/acs-4\/index-eng.php).","DOI":"10.14745\/ccdr.v36i00a04"},{"key":"S0950268815000734_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"S0950268815000734_ref31","doi-asserted-by":"publisher","DOI":"10.1177\/1757177411402409"},{"key":"S0950268815000734_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12560-014-9145-5"},{"key":"S0950268815000734_ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011599"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268815000734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T09:31:24Z","timestamp":1566725484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268815000734\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,20]]},"references-count":36,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0950268815000734"],"URL":"https:\/\/doi.org\/10.1017\/s0950268815000734","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,20]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press and the Government of Canada, represented by the Public Health Agency of Canada 2015\u00a0This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/3.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}