{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:14:34Z","timestamp":1759011274889},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Household contacts of an index case of invasive meningococcal disease (IMD) are at increased risk of acquiring disease. In revising WHO guidance on IMD in sub-Saharan Africa, a systematic review was undertaken to assess the effect of chemoprophylaxis and of vaccination in preventing subsequent cases of IMD in household contacts following an index case. A literature search for systematic reviews identified a single suitable review on chemoprophylaxis in 2004 (three studies meta-analysed). A search for primary research papers published since 2004 on chemoprophylaxis and without a date limit on vaccination was therefore undertaken. There were 2381 studies identified of which two additional studies met the inclusion criteria. The summary risk ratio for chemoprophylaxis <jats:italic>vs.<\/jats:italic> no chemoprophylaxis (four studies) in the 30-day period after a case was 0\u00b716 [95% confidence interval (CI) 0\u00b704-0\u00b764, <jats:italic>P<\/jats:italic> = 0\u00b7008]; the number needed to treat to prevent one subsequent case was 200 (95% CI 111-1000). A single quasi-randomized trial assessed the role of vaccination. The risk ratio for vaccination <jats:italic>vs.<\/jats:italic> no vaccination at 30 days was 0\u00b711 (95% CI 0\u00b701\u20132\u00b707, <jats:italic>P<\/jats:italic> = 0\u00b714). The results support the use of chemoprophylaxis to prevent subsequent cases of IMD in household contacts of a case. Conclusions about the use of vaccination could not be drawn.<\/jats:p>","DOI":"10.1017\/s0950268815000849","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T05:59:15Z","timestamp":1430200755000},"page":"2259-2268","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Chemoprophylaxis and vaccination in preventing subsequent cases of meningococcal disease in household contacts of a case of meningococcal disease: a systematic review"],"prefix":"10.1017","volume":"143","author":[{"given":"L.","family":"TELISINGHE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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