{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:55:08Z","timestamp":1792929308212,"version":"4.5.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T00:00:00Z","timestamp":1432252800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    Porcine reproductive and respiratory syndrome (PRRS) outbreaks in pigs are associated with increased susceptibility of pigs to secondary bacterial infections, including\n                    <jats:italic>Streptococcus suis<\/jats:italic>\n                    \u2013 an important zoonotic pathogen causing bacterial meningitis in humans. This case-control study examined the association between human\n                    <jats:italic>S. suis<\/jats:italic>\n                    infection and PRRS outbreaks in pigs in northern Vietnam. We included 90\n                    <jats:italic>S. suis<\/jats:italic>\n                    case-patients and 183 non-\n                    <jats:italic>S. suis<\/jats:italic>\n                    sepsis controls from a referral hospital in Hanoi in 2010, a period of major PRRS epizootics in Vietnam. PRRS exposure was determined using data from the National Centre of Veterinary Diagnosis. By univariate analysis, significantly more\n                    <jats:italic>S. suis<\/jats:italic>\n                    patients were reported residing in or adjacent to a PRRS district compared to controls [odds ratio (OR) 2\u00b782, 95% confidence interval (CI) 1\u00b735\u20135\u00b789 and OR 3\u00b715, 95% CI 1\u00b762\u20136\u00b715, respectively]. Only residency in adjacent districts remained significantly associated with risk of\n                    <jats:italic>S. suis<\/jats:italic>\n                    infection after adjusting for sex, occupation, and eating practices. SaTScan analysis showed a possible cluster of\n                    <jats:italic>S. suis<\/jats:italic>\n                    infection in humans around PRRS confirmed locations during the March\u2013August period. The findings indicate an epidemiological association between PRRS in pigs and\n                    <jats:italic>S. suis<\/jats:italic>\n                    infections in humans. Effective strategies to strengthen control of PRRS in pigs may help reduce transmission of\n                    <jats:italic>S. suis<\/jats:italic>\n                    infection to humans.\n                  <\/jats:p>","DOI":"10.1017\/s0950268815000990","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T03:10:20Z","timestamp":1432264220000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":25,"title":["Temporal and spatial association of\n                    <i>Streptococcus suis<\/i>\n                    infection in humans and porcine reproductive and respiratory syndrome outbreaks in pigs in northern Vietnam"],"prefix":"10.1017","volume":"144","author":[{"given":"V. T. L.","family":"HUONG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. V.","family":"THANH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. D.","family":"PHU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. T.","family":"TRINH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"INUI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"TUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. T. K.","family":"OANH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. V.","family":"TRUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. T.","family":"HOA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"BRYANT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W.","family":"HORBY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. V.","family":"KINH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. F. L.","family":"WERTHEIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,5,22]]},"reference":[{"key":"S0950268815000990_ref18","article-title":"Using the SaTScan method to detect local malaria clusters for guiding malaria control programmes","author":"Coleman","journal-title":"Malaria Journal"},{"key":"S0950268815000990_ref16","doi-asserted-by":"publisher","DOI":"10.1080\/03610929708831995"},{"key":"S0950268815000990_ref24","first-page":"2189","volume-title":"Livestock Diseases Prevention, Control and Compensation Schemes: Prevention, Control and Compensation Schemes","year":"2012"},{"key":"S0950268815000990_ref23","unstructured":"Nguyen T . PRRS Control in the Region. Compendium of Technical Items of the 28th Conference of the OIE Regional Commission for Asia, the Far East and OceaniaWorld Organisation for Animal Health, 2013 (http:\/\/www.oie.int\/publications-and-documentation\/compendium-of-technical-items\/). Accessed 16 March 2015."},{"key":"S0950268815000990_ref1","doi-asserted-by":"publisher","DOI":"10.1086\/596763"},{"key":"S0950268815000990_ref26","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.7.3232-3239.2002"},{"key":"S0950268815000990_ref22","doi-asserted-by":"publisher","DOI":"10.3201\/eid2011.140915"},{"key":"S0950268815000990_ref13","doi-asserted-by":"publisher","DOI":"10.1136\/vr.134.3.60"},{"key":"S0950268815000990_ref6","article-title":"Risk factors of Streptococcus suis infection in Vietnam. A case-control study","author":"Nghia","journal-title":"PLoS ONE"},{"key":"S0950268815000990_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66379-9"},{"key":"S0950268815000990_ref2","article-title":"Streptococcus suis, an important pig pathogen and emerging zoonotic agent \u2013 an update on the worldwide distribution based on serotyping and sequence typing","author":"Goyette-Desjardins","journal-title":"Emerging Microbes and Infections"},{"key":"S0950268815000990_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01272.x"},{"key":"S0950268815000990_ref3","doi-asserted-by":"publisher","DOI":"10.3201\/eid2007.131594"},{"key":"S0950268815000990_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-184"},{"key":"S0950268815000990_ref9","volume-title":"\u2018Focus on \u2026\u2019 series","author":"Dietze","year":"2011"},{"key":"S0950268815000990_ref10","doi-asserted-by":"publisher","DOI":"10.4038\/tar.v23i2.4646"},{"key":"S0950268815000990_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.6.1343"},{"key":"S0950268815000990_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2010.01.004"},{"key":"S0950268815000990_ref11","doi-asserted-by":"publisher","DOI":"10.3201\/eid1902.120470"},{"key":"S0950268815000990_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1865-1682.2010.01152.x"},{"key":"S0950268815000990_ref21","first-page":"157","article-title":"Pig illnesses and epidemics: a qualitative study on perceptions and practices of pig raisers in Bangladesh","volume":"48","author":"Nahar","year":"2012","journal-title":"Veterinaria Italiana"},{"key":"S0950268815000990_ref8","doi-asserted-by":"publisher","DOI":"10.2174\/1874914300902010052"},{"key":"S0950268815000990_ref5","article-title":"Streptococcus suis, an important cause of adult bacterial meningitis in northern Vietnam","author":"Wertheim","journal-title":"PLoS ONE"},{"key":"S0950268815000990_ref12","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.10.4889-4895.2001"},{"key":"S0950268815000990_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05778-6"},{"key":"S0950268815000990_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2013.12.009"},{"key":"S0950268815000990_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2010.07.016"},{"key":"S0950268815000990_ref4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1086\/527385","article-title":"Streptococcus suis meningitis in adults in Vietnam","volume":"46","author":"Mai","year":"2008","journal-title":"Clinical Infectious Diseases"},{"key":"S0950268815000990_ref27","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-2-143"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268815000990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T20:35:14Z","timestamp":1555706114000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268815000990\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,22]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0950268815000990"],"URL":"https:\/\/doi.org\/10.1017\/s0950268815000990","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,22]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2015\u00a0This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/3.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}