{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:34:40Z","timestamp":1761896080686},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Extended-spectrum <jats:italic>\u03b2<\/jats:italic>-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) have recently emerged in livestock and humans. Therefore, this study assessed the carriage of Enterobacteriaceae in the anterior nares and associated antimicrobial resistance in pig-exposed persons. Nasal swabs were enriched in non-selective broth and then plated on MacConkey and ESBL-selective agars. Species was confirmed by matrix-assisted laser-desorption ionization\u2013time-of-flight mass spectrometry (MALDI-ToF MS). Antimicrobial susceptibility testing was performed according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines. Of 114 pig-exposed persons tested, Enterobacteriaceae were detected in the nares of 76 (66\u00b77%) participants. The predominant species were <jats:italic>Proteus mirabilis<\/jats:italic> (<jats:italic>n<\/jats:italic> = 17, 14\u00b79%), <jats:italic>Pantoea agglomerans<\/jats:italic> (<jats:italic>n<\/jats:italic> = 13, 11\u00b74%), <jats:italic>Morganella morganii<\/jats:italic> (<jats:italic>n<\/jats:italic> = 9, 7\u00b79%), <jats:italic>Citrobacter koseri<\/jats:italic> (<jats:italic>n<\/jats:italic> = 9, 7\u00b79%), <jats:italic>Klebsiella pneumoniae, Escherichia coli<\/jats:italic> and <jats:italic>Proteus vulgaris<\/jats:italic> (each <jats:italic>n<\/jats:italic> = 8, 7\u00b70%). ESBL-E were not detected. Of all isolates tested, 3\u00b74% were resistant against ciprofloxacin, 2\u00b73% against gentamicin, 23\u00b79% against trimethoprim-sulfamethoxazole and 44\u00b73% against tigecycline. Despite the high prevalence of ESBL-E in livestock, pig-exposed persons did not carry ESBL-E in their nares. This finding is important, because colonization of the nasal reservoir might cause endogenous infections or facilitate transmission of ESBL-E in the general population.<\/jats:p>","DOI":"10.1017\/s0950268815001776","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T01:41:18Z","timestamp":1438134078000},"page":"686-690","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Low-level antimicrobial resistance of Enterobacteriaceae isolated from the nares of pig-exposed persons"],"prefix":"10.1017","volume":"144","author":[{"given":"J.","family":"FISCHER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"HILLE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"MELLMANN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"SCHAUMBURG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"KREIENBROCK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"K\u00d6CK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"S0950268815001776_ref3","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01993-13"},{"key":"S0950268815001776_ref1","first-page":"403","article-title":"On the occurence of Extended-spectrum- and AmpC-beta-lactamase- producing Escherichia coli in livestock: results of selected European studies","volume":"127","author":"Hille","year":"2014","journal-title":"Berliner und Munchener tierarztliche Wochenschrift"},{"key":"S0950268815001776_ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010598"},{"key":"S0950268815001776_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003000-00019"},{"key":"S0950268815001776_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.06.004"},{"key":"S0950268815001776_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2014.06.014"},{"key":"S0950268815001776_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks349"},{"key":"S0950268815001776_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.07.015"},{"key":"S0950268815001776_ref5","first-page":"384","article-title":"The burden of zoonotic MRSA colonization and infection in Germany","volume":"127","author":"K\u00f6ck","year":"2014","journal-title":"Berliner und Munchener tierarztliche Wochenschrift"},{"key":"S0950268815001776_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.02.001"},{"key":"S0950268815001776_ref8","doi-asserted-by":"publisher","DOI":"10.1556\/EuJMI.2.2012.3.6"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268815001776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T17:57:21Z","timestamp":1555696641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268815001776\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,29]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0950268815001776"],"URL":"https:\/\/doi.org\/10.1017\/s0950268815001776","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,29]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}