{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:50:37Z","timestamp":1759009837727},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A\/California\/07\/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A\/Victoria\/208\/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B\/Victoria and B\/Yamagata lineages was detected, with B\/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses.<\/jats:p>","DOI":"10.1017\/s0950268815001806","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T03:05:11Z","timestamp":1441681511000},"page":"751-767","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Influenza virus surveillance in Argentina during the 2012 season: antigenic characterization, genetic analysis and antiviral susceptibility"],"prefix":"10.1017","volume":"144","author":[{"given":"E.","family":"BENEDETTI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"DANIELS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"PONTORIERO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"RUSSO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"AVARO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"CZECH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"CAMPOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"PERIOLO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"GREGORY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"McCAULEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. G.","family":"BAUMEISTER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"key":"S0950268815001806_ref26","first-page":"52","article-title":"Current consensus in Vaccines: National Committee of Infectious Diseases","volume":"96","author":"Gentile","year":"1998","journal-title":"Updated Vaccines Consensus"},{"key":"S0950268815001806_ref18","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00458-10"},{"key":"S0950268815001806_ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000564"},{"key":"S0950268815001806_ref30","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq010"},{"key":"S0950268815001806_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.07.017"},{"key":"S0950268815001806_ref31","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1177\/135965350601100804","article-title":"Impact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds","volume":"11","author":"Abed","year":"2006","journal-title":"Antiviral Therapy"},{"key":"S0950268815001806_ref33","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01417-09"},{"key":"S0950268815001806_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12013"},{"key":"S0950268815001806_ref28","first-page":"437","article-title":"Recommended composition of influenza virus vaccines for use in the 2014 southern hemisphere influenza season","volume":"88","year":"2013","journal-title":"Weekly Epidemiological Rcord"},{"key":"S0950268815001806_ref15","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.15.8418-8425.2003"},{"key":"S0950268815001806_ref29","unstructured":"WHO. Summary of influenza antiviral susceptibility surveillance findings, September 2010\u2013March 2011 (http:\/\/www.who.int\/influenza\/gisrs_laboratory\/updates\/antiviral_susceptibility\/en\/)."},{"key":"S0950268815001806_ref7","first-page":"366","article-title":"Recommended composition of influenza virus vaccines for use in the 2009 southern hemisphere influenza season","volume":"83","year":"2008","journal-title":"Weekly Epidemiological Record"},{"key":"S0950268815001806_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90362-2"},{"key":"S0950268815001806_ref23","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810002037"},{"key":"S0950268815001806_ref14","first-page":"97","volume-title":"Global Influenza Surveillance Network Manual for the Laboratory Diagnosis and Virological Surveillance of Influenza","year":"2011"},{"key":"S0950268815001806_ref20","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.2.742-750.2003"},{"key":"S0950268815001806_ref1","first-page":"575","article-title":"Influenza surveillance in nine consecutive seasons, 2003\u20132012: results from National Influenza Reference Laboratory, Istanbul Faculty of Medicine, Turkey","volume":"46","author":"Akcay","year":"2012","journal-title":"Mikrobiyoloji Bulteni"},{"key":"S0950268815001806_ref17","first-page":"43","volume-title":"Global Influenza Surveillance Network Manual for the Laboratory Diagnosis and Virological Surveillance of Influenza","year":"2011"},{"key":"S0950268815001806_ref8","first-page":"81","article-title":"Recommended composition of influenza virus vaccines for use in the 2008\u20132009 influenza season","volume":"83","year":"2008","journal-title":"Weekly Epidemiological Record"},{"key":"S0950268815001806_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0351-z"},{"key":"S0950268815001806_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2004.02.034"},{"key":"S0950268815001806_ref13","first-page":"369","article-title":"Meetings of the WHO working group on surveillance of influenza antiviral susceptibility \u2013 Geneva, November 2011 and June 2012","volume":"87","year":"2012","journal-title":"Weekly Epidemiological Record"},{"key":"S0950268815001806_ref35","article-title":"Contribution of the Portuguese laboratory network for the diagnosis of influenza A(H1N1)pdm09 infection during the 2009\/10 and 2010\/11 influenza seasons","volume":"17","author":"Guiomar","year":"2012","journal-title":"Eurosurveillance"},{"key":"S0950268815001806_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.07.089"},{"key":"S0950268815001806_ref27","doi-asserted-by":"publisher","DOI":"10.4161\/hv.18569"},{"key":"S0950268815001806_ref9","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0102"},{"key":"S0950268815001806_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00160-8"},{"key":"S0950268815001806_ref22","unstructured":"WHO. 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Accessed 23 August 2013."},{"key":"S0950268815001806_ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057154"},{"key":"S0950268815001806_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.11.043"},{"key":"S0950268815001806_ref34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018956"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268815001806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T14:21:12Z","timestamp":1653142872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268815001806\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0950268815001806"],"URL":"https:\/\/doi.org\/10.1017\/s0950268815001806","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,8]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2015\u00a0This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}