{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:10:11Z","timestamp":1792253411873,"version":"4.4.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Shiga-toxin-producing<jats:italic>Escherichia coli<\/jats:italic>(STEC) infections usually cause haemolytic uraemic syndrome (HUS) equally in male and female children. This study investigated the localization of globotriaosylceramide (Gb3) in human brain and kidney tissues removed from forensic autopsy cases in Japan. A fatal case was used as a positive control in an outbreak of diarrhoeal disease caused by STEC O157:H7 in a kindergarten in Urawa in 1990. Positive immunodetection of Gb3 was significantly more frequent in female than in male distal and collecting renal tubules. To correlate this finding with a clinical outcome, a retrospective analysis of the predictors of renal failure in the 162 patients of two outbreaks in Japan was performed: one in Tochigi in 2002 and the other in Kagawa Prefecture in 2005. This study concludes renal failure, including HUS, was significantly associated with female sex, and the odds ratio was 4\u00b706 compared to male patients in the two outbreaks. From 2006 to 2009 in Japan, the risk factor of HUS associated with STEC infection was analysed. The number of males and females and the proportion of females who developed HUS were calculated by age and year from 2006 to 2009. In 2006, 2007 and 2009 in adults aged &gt;20 years, adult women were significantly more at risk of developing HUS in Japan.<\/jats:p>","DOI":"10.1017\/s0950268815002289","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T06:32:14Z","timestamp":1444977134000},"page":"952-961","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["Risk of haemolytic uraemic syndrome caused by shiga-toxin-producing<i>Escherichia coli<\/i>infection in adult women in Japan"],"prefix":"10.1017","volume":"144","author":[{"given":"J.","family":"FUJII","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"MIZOUE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"KITA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"KISHIMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"JOH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"NAKADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"UGAJIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"NAYA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"NAKAMURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"TADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"OKABE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"MARUYAMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"SAITOH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"KUROZAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"key":"S0950268815002289_ref24","first-page":"357","article-title":"Effect of early fosfomycin treatment on prevention of hemolytic uremic syndrome accompanying Escherichia coli O157:H7 infection","volume":"52","author":"Ikeda","year":"1999","journal-title":"Clinical Nephrology"},{"key":"S0950268815002289_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010082"},{"key":"S0950268815002289_ref23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1542\/peds.65.1.115","article-title":"The importance of nonrenal involvement in hemolytic-uremic syndrome","volume":"65","author":"Upadhyaya","year":"1980","journal-title":"Pediatrics"},{"key":"S0950268815002289_ref27","doi-asserted-by":"publisher","DOI":"10.3201\/eid1104.040739"},{"key":"S0950268815002289_ref13","doi-asserted-by":"crossref","first-page":"8834","DOI":"10.1016\/S0021-9258(18)47490-X","article-title":"Glycolipid binding of purified and recombinant Escherichia coli produced verotoxin in vitro","volume":"262","author":"Lingwood","year":"1987","journal-title":"Journal of Biological Chemistry"},{"key":"S0950268815002289_ref26","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-9-199511010-00009"},{"key":"S0950268815002289_ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106920"},{"key":"S0950268815002289_ref28","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800067583"},{"key":"S0950268815002289_ref10","unstructured":"Okajima S . 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