{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:51:09Z","timestamp":1794109869667,"version":"4.8.0"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T00:00:00Z","timestamp":1445472000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Large outbreaks of Q fever have recently increased the awareness of this disease as a public health issue. Knowledge of the general impact of Q fever relies mainly on seroprevalence studies and it is fundamental that seroprevalence is assessed accurately. Therefore we evaluated the few enzyme-linked immunosorbent assays (ELISAs) commercially available for this purpose. An outbreak in 2005 in Jena, a city of 100 000 inhabitants, gave us the opportunity for the evaluation. However, we found disappointingly low sensitivities for two (42% and 51%) of three commercial ELISAs for detecting past infection. Nevertheless, all assays had good classification potential but cut-off adaptation is needed. Based on the unequal worldwide distribution of the differently performing tests in studies, Q fever seroprevalence is likely to be underestimated in studies from Europe whereas the data from North America and Australia are likely to be more reliable.<\/jats:p>","DOI":"10.1017\/s0950268815002447","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T04:31:23Z","timestamp":1445488283000},"page":"1148-1152","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Enzyme-linked immunosorbent assays in seroprevalence studies of Q fever: the need for cut-off adaptation and the consequences for prevalence data"],"prefix":"10.1017","volume":"144","author":[{"given":"J.","family":"FROSINSKI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"HERMANN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"MAIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"BODEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,10,22]]},"reference":[{"key":"S0950268815002447_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp077"},{"key":"S0950268815002447_ref7","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2012.664777"},{"key":"S0950268815002447_ref10","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00322-12"},{"key":"S0950268815002447_ref1","doi-asserted-by":"crossref","DOI":"10.2807\/ese.15.12.19520-en","article-title":"Q fever in the Netherlands: an update on the epidemiology and control measures","volume":"15","author":"van der Hoek","year":"2010","journal-title":"Eurosurveillance"},{"key":"S0950268815002447_ref3","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-255"},{"key":"S0950268815002447_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hci009"},{"key":"S0950268815002447_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03250.x"},{"key":"S0950268815002447_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JCM.34.1.1-9.1996","article-title":"Evolution of the serologic response to Borrelia burgdorferi in treated patients with culture-confirmed erythema migrans","volume":"34","author":"Aguero-Rosenfeld","year":"1996","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268815002447_ref11","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2011.0879"},{"key":"S0950268815002447_ref6","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.9.3526-3529.2002"},{"key":"S0950268815002447_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268811000021"},{"key":"S0950268815002447_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268807009533"},{"key":"S0950268815002447_ref12","first-page":"1","article-title":"Coxiella burnetii (Q fever) as a cause of community-acquired pneumonia during the warm season in Germany","volume":"20","author":"Schack","year":"2013","journal-title":"Epidemiology and Infection"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268815002447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T21:28:22Z","timestamp":1653341302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268815002447\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,22]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0950268815002447"],"URL":"https:\/\/doi.org\/10.1017\/s0950268815002447","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,22]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}