{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:00:25Z","timestamp":1791277225266,"version":"4.1.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T00:00:00Z","timestamp":1447027200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Necrotizing fasciitis (NF) is a life-threatening infection requiring urgent surgical and medical therapy. Our objective was to estimate the mortality burden of NF in the United States, and to identify time trends in the incidence rate of NF-related mortality. We obtained data from the National Center for Health Statistics, which receives information from death certificates from all states, including demographic information and cause of death. The U.S. Multiple Cause of Death Files were searched from 2003 to 2013 for a listing of NF (ICD-10 code M72.6) as either the underlying or contributing cause of death. We identified a total of 9871 NF-related deaths in the United States between 2003 and 2013, corresponding to a crude mortality rate of 4\u00b78 deaths\/1 000 000 person-years, without a significant time trend. Compared to white individuals, the incidence rate of NF-associated death was greater in black, Hispanic, and American Indian individuals, and lower in Asian individuals. Streptococcal infection was most commonly identified in cases where a pathogen was reported. Diabetes mellitus and obesity were more commonly observed in NF-related deaths compared to deaths due to other causes. Racial differences in the incidence of NF-related deaths merits further investigation.<\/jats:p>","DOI":"10.1017\/s0950268815002745","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T04:47:38Z","timestamp":1447044458000},"page":"1338-1344","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":83,"title":["Deaths from necrotizing fasciitis in the United States, 2003\u20132013"],"prefix":"10.1017","volume":"144","author":[{"given":"N.","family":"ARIF","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"YOUSFI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"VINNARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,11,9]]},"reference":[{"key":"S0950268815002745_ref22","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268809002532"},{"key":"S0950268815002745_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880500484X"},{"key":"S0950268815002745_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.07.019"},{"key":"S0950268815002745_ref28","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530340058030"},{"key":"S0950268815002745_ref3","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1086\/511638","article-title":"Necrotizing soft-tissue infection: diagnosis and management","volume":"44","author":"Anaya","year":"2007","journal-title":"Clinical Infectious Diseases"},{"key":"S0950268815002745_ref24","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182a84a43"},{"key":"S0950268815002745_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000129486.35458.7D"},{"key":"S0950268815002745_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7495.830"},{"key":"S0950268815002745_ref9","doi-asserted-by":"publisher","DOI":"10.1086\/521264"},{"key":"S0950268815002745_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.02.029"},{"key":"S0950268815002745_ref13","unstructured":"CDC. National vital statistics system. United States bridged-race population estimates, 2010 \u2013 NCHS (http:\/\/www.cdc.gov\/nchs\/nvss\/bridged_race.htm)."},{"key":"S0950268815002745_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.11.026"},{"key":"S0950268815002745_ref26","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268806007448"},{"key":"S0950268815002745_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2012.09.039"},{"key":"S0950268815002745_ref11","unstructured":"WHO. International Classification of Diseases, 10th Revision, 1992 (www.who.int\/classifications\/icd\/en\/)."},{"key":"S0950268815002745_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.10.032"},{"key":"S0950268815002745_ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000180"},{"key":"S0950268815002745_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.2.151"},{"key":"S0950268815002745_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu296"},{"key":"S0950268815002745_ref20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-1084OC"},{"key":"S0950268815002745_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv071"},{"key":"S0950268815002745_ref12","unstructured":"WHO. Instruction for Classifying the Underlying Cause of Death, 2013. Hyattsville: National Center for Health Statistics, 2013 (www.cdc.gov\/nchs\/data\/dvs\/2a_2013.pdf)."},{"key":"S0950268815002745_ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.851"},{"key":"S0950268815002745_ref27","doi-asserted-by":"publisher","DOI":"10.1086\/383471"},{"key":"S0950268815002745_ref7","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1128\/JCM.33.9.2382-2387.1995","article-title":"Clinical and microbiological features of necrotizing fasciitis","volume":"33","author":"Brook","year":"1995","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268815002745_ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042683"},{"key":"S0950268815002745_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm037"},{"key":"S0950268815002745_ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/618067"},{"key":"S0950268815002745_ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-348"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268815002745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T23:56:23Z","timestamp":1599782183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268815002745\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,9]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0950268815002745"],"URL":"https:\/\/doi.org\/10.1017\/s0950268815002745","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,9]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}