{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:06:39Z","timestamp":1790798799430,"version":"4.1.0"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>Acinetobacter baumannii<\/jats:italic> is a significant nosocomial pathogen often associated with extreme drug resistance (XDR). In Argentina, isolates of <jats:italic>A. baumannii<\/jats:italic> resistant to tetracyclines have accounted for more than 40% of drug-resistant isolates in some hospitals. We have previously reported the dispersion of the <jats:italic>tet<\/jats:italic>(B) resistance element associated with the IS<jats:italic>CR2<\/jats:italic> transposase in epidemiologically unrelated <jats:italic>A. baumannii<\/jats:italic> isolates recovered from 1983 to 2011. This study extends this surveillance to 77 recent (2009\u20132013) XDR <jats:italic>A. baumannii<\/jats:italic> isolates with different levels of minocycline susceptibility. Isolates were examined by a pan-PCR assay, which showed six different amplification patterns, and specific PCRs were used for the confirmation of the the \u0394IS<jats:italic>CR2-tet<\/jats:italic>(B)-<jats:italic>tet<\/jats:italic>(R)-IS<jats:italic>CR2<\/jats:italic> element. The <jats:italic>tet<\/jats:italic>(B) gene was present in 66 isolates and the IS<jats:italic>CR2<\/jats:italic> element in 68 isolates; the <jats:italic>tet<\/jats:italic>(B) gene was associated with IS<jats:italic>CR2<\/jats:italic> in all <jats:italic>tet<\/jats:italic>(B)-positive isolates. We conclude that this element is widespread in XDR <jats:italic>A. baumannii<\/jats:italic> isolates from Argentina and could be responsible for the emergence of tetracycline resistance in recent years.<\/jats:p>","DOI":"10.1017\/s0950268815002897","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T04:52:17Z","timestamp":1447995137000},"page":"1574-1578","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["Widespread dispersion of the resistance element <i>tet<\/i>(B)::IS<i>CR2<\/i> in XDR <i>Acinetobacter baumannii<\/i> isolates"],"prefix":"10.1017","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3528-6497","authenticated-orcid":false,"given":"E.","family":"VILACOBA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ALMUZARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"GULONE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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