{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T03:47:30Z","timestamp":1648612050873},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Various variables that might influence the rapid and sustained virological response to recombinant PEG-IFN-<jats:italic>\u03b1<\/jats:italic>-2a were explored in Iraqi HCV-infected patients with haemoglobinopathy. Forty-three patients were evaluated for the relationship between rapid virological response (RVR), IL-28B polymorphism, viral load, liver enzyme levels, blood group, ultrasound findings, or HCV genotype and the sustained virological response (SVR) achievement. The overall RVR was 55\u00b781% while the overall SVR was 53\u00b749%. SVR in patients that achieved RVR was 82\u00b761% (<jats:italic>P<\/jats:italic> = 0\u00b70004). A significant association was found between initial alanine transaminase levels and viral load with SVR achievement (<jats:italic>P<\/jats:italic> = 0\u00b7025) and (<jats:italic>P<\/jats:italic> = 0\u00b7004), respectively. Thirty-two (74%) out of 43 of our samples were host genotyped at the IL-28B locus as CC, a significant association was found between CC group and SVR achievement (<jats:italic>P<\/jats:italic> = 0\u00b704). Of our samples, 23\/43 (53%) were typed as HCV genotype 4, 10\/43 (23%) as genotype 1, 9\/43 (20\u00b79%) as genotype 3 and 1\/43 (2\u00b73%) as genotype 2. A significant association was found between genotype 3 and SVR achievement (<jats:italic>P<\/jats:italic> = 0\u00b7006). Multivariate analysis showed that only RVR achievement independently associated with SVR in the Iraqi population (<jats:italic>P<\/jats:italic> = 0\u00b700). These results can be used to classify the patients requiring the more expensive new direct-acting antiviral drugs.<\/jats:p>","DOI":"10.1017\/s0950268815003064","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T08:57:55Z","timestamp":1449824275000},"page":"1634-1640","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["The treatment of HCV in patients with haemoglobinopathy in Kurdistan Region, Iraq: a single centre experience"],"prefix":"10.1017","volume":"144","author":[{"given":"N. R.","family":"HUSSEIN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"TUNJEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"BASHARAT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"TAHA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"IRVING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"S0950268815003064_ref18","first-page":"204","article-title":"Seroprevalence of hepatitis C virus specific antibodies among Iraqi children with thalassaemia","volume":"12","author":"Al-Kubaisy","year":"2006","journal-title":"Eastern Mediterranean Health Journal"},{"key":"S0950268815003064_ref22","doi-asserted-by":"publisher","DOI":"10.1038\/ng.447"},{"key":"S0950268815003064_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.057182"},{"key":"S0950268815003064_ref5","first-page":"11","article-title":"Treatment of HCV infection in multitransfused thalassemic patients: does liver iron status affect the outcome of response","volume":"5","author":"Mirmomen","year":"2005","journal-title":"Hepatitis Monthly"},{"key":"S0950268815003064_ref8","doi-asserted-by":"publisher","DOI":"10.1086\/523585"},{"key":"S0950268815003064_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200207000-00017"},{"key":"S0950268815003064_ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099468"},{"key":"S0950268815003064_ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-248724"},{"key":"S0950268815003064_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23912"},{"key":"S0950268815003064_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2010.08.003"},{"key":"S0950268815003064_ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078142"},{"key":"S0950268815003064_ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ng.449"},{"key":"S0950268815003064_ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct061675"},{"key":"S0950268815003064_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21583"},{"key":"S0950268815003064_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"S0950268815003064_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f1da99"},{"key":"S0950268815003064_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27259"},{"key":"S0950268815003064_ref6","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.778-809.2001"},{"key":"S0950268815003064_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.03.029"},{"key":"S0950268815003064_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20170"},{"key":"S0950268815003064_ref17","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.6592"},{"key":"S0950268815003064_ref7","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.17.9285-9294.2004"},{"key":"S0950268815003064_ref2","doi-asserted-by":"publisher","DOI":"10.5272\/jimab.2011171.197"},{"key":"S0950268815003064_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/BF01718613"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268815003064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T04:23:25Z","timestamp":1555647805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268815003064\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,9]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0950268815003064"],"URL":"https:\/\/doi.org\/10.1017\/s0950268815003064","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,9]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}