{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T04:45:37Z","timestamp":1766551537376,"version":"3.37.3"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Cytomegalovirus (CMV) is the leading cause of congenital infection and non-genetic sensorineural hearing loss in children. There are no recent data on the incidence of CMV infection during pregnancy in Canada. This present study was undertaken to determine the seroprevalence of CMV IgG antibodies and the rate of seroconversion in a cohort of pregnant women in the province of Qu\u00e9bec, Canada. We used serum samples and questionnaire data collected as part of the 3D Pregnancy and Birth Cohort Study (2010\u20132013) conducted in Qu\u00e9bec, Canada. CMV IgG antibodies were determined in serum samples collected at the first and third trimesters. Associations between independent variables and seroprevalence were assessed using logistic regression, and associations with seroconversions, by Poisson regression. Of 1938 pregnant women tested, 40\u00b74% were seropositive for CMV at baseline. Previous CMV infection was associated with: working as a daycare educator, lower education, lower income, having had children, first language other than French or English, and being born outside Canada or the United States. Of the 1122 initially seronegative women, 24 (2\u00b71%) seroconverted between their first and third trimesters. The seroconversion rate was 1\u00b74 [95% confidence interval (CI) 0\u00b79\u20132\u00b71]\/10 000 person-days at risk or 3\u00b79 (95% CI 2\u00b75\u20135\u00b79)\/100 pregnancies (assuming a 280-day gestation). The high proportion of pregnant women susceptible to CMV infection (nearly 60%) and the subsequent rate of seroconversion are of concern.<\/jats:p>","DOI":"10.1017\/s0950268815003167","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T05:58:04Z","timestamp":1450677484000},"page":"1701-1709","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":24,"title":["Seroconversion for cytomegalovirus infection in a cohort of pregnant women in Qu\u00e9bec, 2010\u20132013"],"prefix":"10.1017","volume":"144","author":[{"given":"V.","family":"LAMARRE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6985-8046","authenticated-orcid":false,"given":"N. L.","family":"GILBERT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"ROUSSEAU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. W.","family":"GYORKOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. D.","family":"FRASER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"doi-asserted-by":"publisher","key":"S0950268815003167_ref10","DOI":"10.1016\/j.ajog.2008.08.037"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref29","DOI":"10.1097\/00006454-199603000-00013"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref13","DOI":"10.1093\/occmed\/kqi121"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref9","DOI":"10.1093\/infdis\/163.3.460"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref11","DOI":"10.1097\/00006454-199007000-00003"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref16","DOI":"10.1093\/oxfordjournals.aje.a115507"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref18","DOI":"10.1002\/rmv.655"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref14","DOI":"10.1128\/CVI.05228-11"},{"unstructured":"Fraser W , 3-D Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario (IRNPQEO). Canadian National Perinatal Research Meeting Banff, Canada, 2014.","key":"S0950268815003167_ref15"},{"unstructured":"Rose R . Women and the workplace in Qu\u00e9bec: statistical portrait. Montr\u00e9al, Qu\u00e9bec, Canada: Consultative committee Women in workforce development, 2013.","key":"S0950268815003167_ref23"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref6","DOI":"10.1002\/pd.4118"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref12","DOI":"10.1097\/00006454-199606000-00007"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref20","DOI":"10.1002\/rmv.659"},{"key":"S0950268815003167_ref28","first-page":"248","article-title":"Cytomegalovirus infection in pregnancy","volume":"32","year":"2010","journal-title":"Journal of Obstetrics and Gynaecology Canada"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref8","DOI":"10.1056\/NEJM198911093211903"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref17","DOI":"10.1017\/S0950268808000551"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref27","DOI":"10.1097\/01.AOG.0000466430.19823.53"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref7","DOI":"10.1056\/NEJM199203053261003"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref1","DOI":"10.1002\/rmv.535"},{"unstructured":"Public Health Agency of Canada. What Mothers Say: the Canadian Maternity Experiences Survey. Ottawa, Canada, 2009, 225 pp.","key":"S0950268815003167_ref31"},{"key":"S0950268815003167_ref22","first-page":"41","volume-title":"Qu\u00e9bec's Demographical Report","author":"Girard","year":"2014"},{"key":"S0950268815003167_ref4","first-page":"724","volume-title":"Infectious Diseases of the Fetus and Newborn","author":"Britt","year":"2015"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref3","DOI":"10.1002\/rmv.544"},{"volume-title":"Longitudinal Study of the Development of Qu\u00e9bec's Children (ELDEQ 1998\u20132010) \u2013 from Birth to 8 Years of Age","year":"2010","author":"Gigu\u00e8re","key":"S0950268815003167_ref24"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref30","DOI":"10.1016\/j.jpeds.2004.05.041"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref5","DOI":"10.1001\/jama.1986.03380140074025"},{"unstructured":"Wizman S , Risk factors for cytomegalovirus susceptibility among pregnant women: an epidemiological and socio-demographic study. IDWeek 2013. San Francisco, CA, USA, 2013; Abstract 1782.","key":"S0950268815003167_ref25"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref2","DOI":"10.1093\/infdis\/142.5.647"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref19","DOI":"10.1097\/00043764-199811000-00005"},{"doi-asserted-by":"publisher","key":"S0950268815003167_ref26","DOI":"10.1186\/s12905-014-0144-3"},{"unstructured":"Duchesne L . The demographic situation in Qu\u00e9bec \u2013 Report 1999. Qu\u00e9bec's Institute of Statistics, 2000.","key":"S0950268815003167_ref21"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268815003167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:24:04Z","timestamp":1555633444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268815003167\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0950268815003167"],"URL":"https:\/\/doi.org\/10.1017\/s0950268815003167","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"type":"print","value":"0950-2688"},{"type":"electronic","value":"1469-4409"}],"subject":[],"published":{"date-parts":[[2015,12,21]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2015\u00a0This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}