{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:11:50Z","timestamp":1772115110070,"version":"3.50.1"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Over 10% of acute rotavirus gastroenteritis (ARGE) requires hospitalization because of complications. The aggravating factors have been widely analysed, but in an isolated way. We aimed to explore the interrelationship between the clinical and epidemiological factors that characterize rotavirus hospitalizations in Spain using information from the Minimum Basic Data Set (MBDS). Using ICD-9-CM codes, we classified acute gastroenteritis (AGE) cases by principal diagnosis fields and then categorized their comorbidities, complications, and epidemiological features by secondary fields. A multivariable, logistic, step-wise regression model was then constructed. We identified 1657 ARGE cases from 17 415 cases of AGE. Rotavirus hospitalizations were associated with place of residence, age, and season (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001), as well as with dehydration [odds ratio (OR) 12\u00b744, 95% confidence interval (CI) 1\u00b752\u201340\u00b738], intravenous rehydration (OR 1\u00b774, 95% CI 1\u00b729\u20132\u00b735), metabolic acidosis (OR 1\u00b751, 95% CI 1\u00b724\u20131\u00b783), respiratory tract infections (RTIs) (OR 1\u00b760, 95% CI 1\u00b709\u20131\u00b798), and concomitant AGE (OR 1\u00b752, 95% CI 1\u00b703\u20132\u00b725). Dehydration was four times more likely in patients aged &lt;5 years (OR 4\u00b736, 95% CI 1\u00b720\u201312\u00b796) and was associated with acidosis when ARGE and RTI were present simultaneously (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001). Specific co-infecting viruses may play a role in acute respiratory symptoms and aggravation of gastrointestinal manifestations of rotaviruses, thus leading to complications requiring hospitalization.<\/jats:p>","DOI":"10.1017\/s0950268816000881","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T11:05:37Z","timestamp":1462532737000},"page":"2509-2516","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["A multifactorial regression analysis of the features of community-acquired rotavirus requiring hospitalization in Spain as represented in the Minimum Basic Data Set"],"prefix":"10.1017","volume":"144","author":[{"given":"O.","family":"REDONDO-GONZ\u00c1LEZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"TEN\u00cdAS-BURILLO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"S0950268816000881_ref18","doi-asserted-by":"crossref","first-page":"e1278","DOI":"10.1542\/peds.2009-3270","article-title":"Evaluation of a gastroenteritis severity score for use in outpatient settings","volume":"125","author":"Freedman","year":"2010","journal-title":"Pediatrics"},{"key":"S0950268816000881_ref25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1741-7015-11-112","article-title":"Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination","volume":"11","author":"Bruijning-Verhagen","year":"2013","journal-title":"BMC Medicine"},{"key":"S0950268816000881_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.10.017"},{"key":"S0950268816000881_ref28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.eplepsyres.2014.10.021","article-title":"Clinical characteristics of seizures associated with viral gastroenteritis in children","volume":"109","author":"Ueda","year":"2015","journal-title":"Epilepsy Research"},{"key":"S0950268816000881_ref23","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1023\/A:1010931111115","article-title":"Quality of the information contained in the minimum basic data set: results from an evaluation in eight hospitals","volume":"16","author":"Calle","year":"2000","journal-title":"European Journal of Epidemiology"},{"key":"S0950268816000881_ref2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1651-2227.2010.01684.x","article-title":"Rotascore Research Group. Multicenter prospective study analyzing the role of rotavirus on acute gastroenteritis in Spain","volume":"99","author":"Gimenez-S\u00e1nchez","year":"2010","journal-title":"Acta Pediatrica"},{"key":"S0950268816000881_ref32","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.vaccine.2011.11.064","article-title":"Impact of rotavirus vaccination on epidemiological dynamics in England and Wales","volume":"30","author":"Atkins","year":"2012","journal-title":"Vaccine"},{"key":"S0950268816000881_ref8","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/01.inf.0000243777.01375.5b","article-title":"A case-control study to determine risk factors for hospitalization for rotavirus gastroenteritis in U.S","volume":"25","author":"Dennehy","year":"2006","journal-title":"children. 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Madrid: Carlos III Health Institute, 2010."},{"key":"S0950268816000881_ref6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-230X-14-54","article-title":"Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study","volume":"14","author":"Salim","year":"2014","journal-title":"BMC Gastroenterology"},{"key":"S0950268816000881_ref14","first-page":"580","article-title":"Clinical relevance of human bocavirus with acute respiratory tract infection and diarrhea in children: a prospective case-control study","volume":"48","author":"Zeng","year":"2010","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"S0950268816000881_ref29","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1365-2222.2008.03128.x","article-title":"Early-life rotavirus and norovirus infections in relation to development of atopic manifestation in infants","volume":"39","author":"Reimerink","year":"2009","journal-title":"Clinical and 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gastrointestinal motility: prenatal development and problems in infancy","volume":"11","author":"Singendonk","year":"2014","journal-title":"Nature Reviews Gastroenterology and Hepatology"},{"key":"S0950268816000881_ref22","unstructured":"Therapeutic Goods Administration. Document of Rotateq\u00ae product information, September 2008 (http:\/\/www.public.health.wa.gov.au\/cproot\/2220\/2\/RotaTeq%20PI%20%28Sep%202008%29.pdf). Accessed 8 January 2015."},{"key":"S0950268816000881_ref27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.pediatrneurol.2010.03.002","article-title":"Rotavirus gastroenteritis and seizures in young children","volume":"42","author":"Lloyd","year":"2010","journal-title":"Pediatric Neurology"},{"key":"S0950268816000881_ref16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/21645515.2015.1009339","article-title":"Decline in Rotavirus Hospitalizations following the first three years of vaccination in Castile-La Mancha, Spain","volume":"11","author":"Redondo","year":"2015","journal-title":"Human Vaccines and Immunotherapy"},{"key":"S0950268816000881_ref9","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1542\/peds.2007-3378","article-title":"Active, population-based surveillance for severe rotavirus gastroenteritis in children in the United States","volume":"122","author":"Payne","year":"2008","journal-title":"Pediatrics"},{"key":"S0950268816000881_ref15","first-page":"488","article-title":"Clinical study of acute diarrhea caused by rotavirus","volume":"109","author":"Mihalache","year":"2005","journal-title":"Revista medico-chirurgical\u0103\u0306 a Societ\u0103\u0306\u0163\u031cii de Medici \u015f\u0327i Naturali\u015f\u0327ti din Ia\u015f\u0327i"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268816000881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T19:44:21Z","timestamp":1655149461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268816000881\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,6]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0950268816000881"],"URL":"https:\/\/doi.org\/10.1017\/s0950268816000881","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,6]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}