{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:33:14Z","timestamp":1769063594487,"version":"3.49.0"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"15","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The increasing prevalence of extended-spectrum<jats:italic>\u03b2<\/jats:italic>-lactamase (ESBL)-producing Gram-negative bacteria is a serious threat for current healthcare settings. In this study we investigated the molecular epidemiology of ESBL-producing<jats:italic>E. coli<\/jats:italic>at the University Medical Center G\u00f6ttingen in Lower Saxony, Germany. All<jats:italic>E. coli<\/jats:italic>isolates with an ESBL phenotype were collected during a 6-month period in 2014. Multilocus sequence typing and CTX-M characterization were performed on 160 isolates. Of the ESBL-producing isolates 95\u00b76% were CTX-M positive. Compared to recent Germany-wide studies, we found CTX-M-1 to occur in higher frequency than CTX-M-15 (44\u00b74%<jats:italic>vs.<\/jats:italic>34\u00b74%). CTX-M-14 and CTX-M-27 were detected at 9\u00b74% and 5\u00b70%, respectively. The globally dominant sequence type (ST) 131, which is often associated with CTX-M-15, occurred at a relatively low rate of 24%. Major non-ST131 sequence types were ST101 (5%), ST58 (5%), ST10 (4\u00b74%), ST38 (4\u00b74%), ST410 (3\u00b78%) and ST453 (3\u00b71%). Several of these major sequence types were previously shown to be associated with livestock farming. Together, our study indicates that<jats:italic>E. coli<\/jats:italic>lineage distribution in individual healthcare settings can significantly differ from average numbers obtained in nationwide studies.<\/jats:p>","DOI":"10.1017\/s0950268816001412","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T10:53:05Z","timestamp":1467283985000},"page":"3300-3304","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Multilocus sequence typing and CTX-M characterization of ESBL-producing<i>E. coli<\/i>: a prospective single-centre study in Lower Saxony, Germany"],"prefix":"10.1017","volume":"144","author":[{"given":"G.","family":"GERHOLD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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