{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:28:29Z","timestamp":1793532509717,"version":"4.5.0"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"15","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The incidence of childhood respiratory infections in Greenland is among the highest globally. We performed a population-based study of 352 Greenlandic children aged 0\u20136 years aiming to describe rates and risk factors for carriage of four key bacteria associated with respiratory infections, their antimicrobial susceptibility and inter-bacterial associations. Nasopharyngeal swabs were tested for <jats:italic>Streptococcus pneumoniae<\/jats:italic> grouped by serotypes included (VT) or not included (NVT) in the 13-valent pneumococcal conjugate vaccine, non-typable <jats:italic>Haemophilus influenzae<\/jats:italic> (NTHi), <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Moraxella catarrhalis. S. pneumoniae<\/jats:italic> was detected from age 2 weeks with a peak carriage rate of 60% in 2-year-olds. Young age and having siblings attending a daycare institution were associated with pneumococcal carriage. Overall co-colonization with \u2a7e2 of the studied bacteria was 52%. NTHi showed a positive association with NVT pneumococci and <jats:italic>M. catarrhalis<\/jats:italic>, respectively, <jats:italic>M. catarrhalis<\/jats:italic> was positively associated with <jats:italic>S. pneumoniae<\/jats:italic>, particular VT pneumococci, whereas <jats:italic>S. aureus<\/jats:italic> were negatively associated with NTHi and <jats:italic>M. catarrhalis.<\/jats:italic> Nasopharyngeal bacterial carriage was present unusually early in life and with frequent co-colonization. Domestic crowding increased odds of carriage. Due to important bacterial associations we suggest future surveillance of pneumococcal conjugate vaccine's impact on carriage in Greenland to also include other pathogens.<\/jats:p>","DOI":"10.1017\/s0950268816001461","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T09:42:39Z","timestamp":1468402959000},"page":"3226-3236","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":34,"title":["Nasopharyngeal bacterial carriage in young children in Greenland: a population at high risk of respiratory infections"],"prefix":"10.1017","volume":"144","author":[{"given":"J. E.","family":"NAVNE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"B\u00d8RRESEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"SLOTVED","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ANDERSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"MELBYE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"LADEFOGED","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"KOCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"S0950268816001461_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61204-6"},{"key":"S0950268816001461_ref30","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-304"},{"key":"S0950268816001461_ref6","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.09.79"},{"key":"S0950268816001461_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.03.024"},{"key":"S0950268816001461_ref41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102083440602"},{"key":"S0950268816001461_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis799"},{"key":"S0950268816001461_ref33","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801206010040"},{"key":"S0950268816001461_ref35","doi-asserted-by":"publisher","DOI":"10.1086\/503805"},{"key":"S0950268816001461_ref36","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.5.1081"},{"key":"S0950268816001461_ref28","doi-asserted-by":"publisher","DOI":"10.3201\/eid0806.010321"},{"key":"S0950268816001461_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis292"},{"key":"S0950268816001461_ref40","doi-asserted-by":"publisher","DOI":"10.3201\/eid1811.111904"},{"key":"S0950268816001461_ref32","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318245a5a8"},{"key":"S0950268816001461_ref31","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06589-11"},{"key":"S0950268816001461_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir730"},{"key":"S0950268816001461_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf506"},{"key":"S0950268816001461_ref25","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.6.2518-2522.2004"},{"key":"S0950268816001461_ref8","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.53"},{"key":"S0950268816001461_ref18","first-page":"441","article-title":"The Danish Civil Registration System","volume":"53","author":"Pedersen","year":"2006","journal-title":"A cohort of eight million persons. Danish Medical Bulletin"},{"key":"S0950268816001461_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2008.08.010"},{"key":"S0950268816001461_ref23","unstructured":"European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 3.1, 2013 (http:\/\/www.eucast.org.)."},{"key":"S0950268816001461_ref14","doi-asserted-by":"publisher","DOI":"10.1371\/annotation\/2b5d32c3-808f-4759-8207-0a953e4ad01d"},{"key":"S0950268816001461_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg143"},{"key":"S0950268816001461_ref34","doi-asserted-by":"publisher","DOI":"10.1086\/425422"},{"key":"S0950268816001461_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001517"},{"key":"S0950268816001461_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.16.1784"},{"key":"S0950268816001461_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.06.017"},{"key":"S0950268816001461_ref24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197303082881007"},{"key":"S0950268816001461_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16357-5"},{"key":"S0950268816001461_ref37","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199906000-00008"},{"key":"S0950268816001461_ref38","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.3.e28"},{"key":"S0950268816001461_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf506"},{"key":"S0950268816001461_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.04.017"},{"key":"S0950268816001461_ref17","unstructured":"Greenland in Figures Greenland. Kalaallit Nunaat, 2013 (http:\/\/www.stat.gl\/dialog\/main.asp?lang=da&version=2013&link=GF&subthemecode=p1&colcode=p.)."},{"key":"S0950268816001461_ref20","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.1.412-414.2004"},{"key":"S0950268816001461_ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103293"},{"key":"S0950268816001461_ref29","doi-asserted-by":"publisher","DOI":"10.3201\/eid1401.071240"},{"key":"S0950268816001461_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000049347.42983.77"},{"key":"S0950268816001461_ref9","doi-asserted-by":"publisher","DOI":"10.1086\/521833"},{"key":"S0950268816001461_ref3","doi-asserted-by":"publisher","DOI":"10.3201\/eid1401.071315"},{"key":"S0950268816001461_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61114-4"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268816001461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T21:29:10Z","timestamp":1555622950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268816001461\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,13]]},"references-count":41,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0950268816001461"],"URL":"https:\/\/doi.org\/10.1017\/s0950268816001461","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,13]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}