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Infect."],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We investigated the antibiotic and heavy-metal resistance mechanisms, virulence genes and clonal relationships of macrolide- and\/or lincosamide-resistant (M+\/\u2212L<jats:sup>R<\/jats:sup>)<jats:italic>Streptococcus agalactiae<\/jats:italic>(group B<jats:italic>Streptococcus<\/jats:italic>, GBS) isolates from pregnant women in La Rioja in Northern Spain, a region with a significant immigrant population. In total 375 GBS isolates were recovered during 2011. About three-quarters of isolates were from European nationals and the remainder distributed among 23 other nationalities. Seventy-five (20%) were classified as M+\/\u2212L<jats:sup>R<\/jats:sup>strains and 28 (37%) of these were resistant to \u2a7e3 classes of antibiotics. Capsular serotypes III (29\u00b73%), V (21\u00b73%) and II (12%) were the most frequent. A wide variety of antibiotic resistance genes were detected in M+\/\u2212L<jats:sup>R<\/jats:sup>strains; notably, 5\u00b73% harboured the<jats:italic>lsa<\/jats:italic>(C) gene associated with cross-resistance, and<jats:italic>tet<\/jats:italic>(W) was identified in a single strain. We report, for the first time, the detection of cadmium and copper resistance encoded by<jats:italic>tcrB<\/jats:italic>+<jats:italic>cadA<\/jats:italic>+<jats:italic>cadC<\/jats:italic>genes in 20 M+\/\u2212L<jats:sup>R<\/jats:sup>strains, which raises the possibility of co-selection of antibiotic and heavy-metal resistance disseminated through mobile genetic elements. The M+\/\u2212L<jats:sup>R<\/jats:sup>strains were highly diverse by DNA macrorestriction profiles (65 patterns) and 16 multilocus sequence types (STs) distributed among six clonal complexes; the most frequent were ST1, ST19, and ST12, and two strains were novel (ST586 and ST601). In conclusion, a wide diversity of genetic lineages of macrolide, lincosamide and heavy-metal- resistant GBS strains was observed in an ethnically diverse maternal population.<\/jats:p>","DOI":"10.1017\/s0950268816001692","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T09:18:13Z","timestamp":1470647893000},"page":"3205-3214","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":28,"title":["<i>Streptococcus agalactiae<\/i>from pregnant women: antibiotic and heavy-metal resistance mechanisms and molecular typing"],"prefix":"10.1017","volume":"144","author":[{"given":"B.","family":"ROJO-BEZARES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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