{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:44:01Z","timestamp":1759063441077},"reference-count":6,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Since the emergence of Middle East respiratory syndrome coronavirus (MERS-CoV), Singapore has enhanced its national surveillance system to detect the potential importation of this novel pathogen. Using the guidelines from the Singapore Ministry of Health, a suspect case was defined as a person with clinical signs and symptoms suggestive of pneumonia or severe respiratory infection with breathlessness, and with an epidemiological link to countries where MERS-CoV cases had been reported within the preceding 14 days. This report describes a retrospective review of 851 suspected MERS-CoV cases assessed at the adult tertiary-care hospital in Singapore between September 2012 and December 2015. In total, 262 patients (31%) were hospitalized. All had MERS-CoV infection ruled out by RT\u2013PCR or clinical assessment. Two hundred and thirty (88%) of the hospitalized patients were also investigated for influenza virus by RT\u2013PCR. Of these, 62 (27%) tested positive for seasonal influenza. None of the patients with positive influenza results had been vaccinated in the year prior to hospital admission. Ninety-three (36%) out of the 262 hospitalized patients had clinical and\/or radiological evidence of pneumonia. This study demonstrates the potential benefits of pre-travel vaccination against influenza and pneumococcal disease.<\/jats:p>","DOI":"10.1017\/s0950268816002326","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T07:39:10Z","timestamp":1477467550000},"page":"285-288","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Risk assessment and laboratory investigation of respiratory illness in travellers returning to Singapore 2012\u20132015: experience from the MERS-CoV Surveillance Programme"],"prefix":"10.1017","volume":"145","author":[{"given":"M. K.","family":"WIN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"CHOW","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"HO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Y.","family":"TAY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. S.","family":"LEO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"S0950268816002326_ref2","unstructured":"Singapore Department of Statistics. (http:\/\/www.singstat.gov.sg\/statistics\/latest-data). Accessed 16 August 2016."},{"key":"S0950268816002326_ref5","unstructured":"World Health Organization. (http:\/\/www.who.int\/csr\/don\/2014_04_17_mers\/en). Accessed 16 August 2016."},{"key":"S0950268816002326_ref4","unstructured":"Singapore Tourism Board. (https:\/\/www.stb.gov.sg\/statistics-and-market-insights). Accessed 16 August 2016."},{"key":"S0950268816002326_ref1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.47102\/annals-acadmedsg.V42N8p376","article-title":"The Middle East respiratory syndrome coronavirus (MERS-CoV) and Singapore","volume":"42","author":"Tambyah","year":"2013","journal-title":"Annals of the Academy of Medicine Singapore"},{"key":"S0950268816002326_ref3","unstructured":"Islamic Religious Council of Singapore. (http:\/\/www.muis.gov.sg). Accessed 16 August 2016."},{"key":"S0950268816002326_ref6","doi-asserted-by":"publisher","DOI":"10.3201\/eid2010.131768"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268816002326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T16:36:11Z","timestamp":1692549371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268816002326\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,26]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0950268816002326"],"URL":"https:\/\/doi.org\/10.1017\/s0950268816002326","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,26]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}