{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:15:23Z","timestamp":1770286523635,"version":"3.49.0"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A latent tuberculosis infection (LTBI) prevalence survey was conducted using tuberculin skin test (TST) and Quantiferon test (QFT) in 1218 healthcare workers (HCWs) in Medell\u00edn, Colombia. In order to improve the prevalence estimates, a latent class model was built using a Bayesian approach with informative priors on the sensitivity and specificity of the TST. The proportion of concordant results (TST+,QFT+) was 41% and the discordant results contributed 27%. The marginal estimate of the prevalence P(LTBI+) was 62\u00b71% [95% credible interval (CrI) 53\u00b70\u201368\u00b72]. The probability of LTBI+ given positive results for both tests was 99\u00b76% (95% CrI 98\u00b71\u201399\u00b79). Sensitivity was 88\u00b75 for TST and 74\u00b73 for QFT, and specificity was 87\u00b78 for TST and 97\u00b76 for QFT. A high LTBI prevalence was found in HCWs with time-accumulated exposure in hospitals that lack control plans. In a context of intermediate tuberculosis (TB) incidence it is recommended to use only one test (either QFT or TST) in prevalence surveys or as pre-employment tests. Results will be useful to help implement TB infection control plans in hospitals where HCWs may be repeatedly exposed to unnoticed TB patients, and to inform the design of TB control policies.<\/jats:p>","DOI":"10.1017\/s0950268816003150","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T02:37:16Z","timestamp":1483929436000},"page":"1095-1106","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of tuberculosis infection in healthcare workers of the public hospital network in Medell\u00edn, Colombia: a Bayesian approach"],"prefix":"10.1017","volume":"145","author":[{"given":"J.","family":"OCHOA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"LE\u00d3N","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. C.","family":"RAM\u00cdREZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"LOPERA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"BERNAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"ARBEL\u00c1EZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"key":"S0950268816003150_ref33","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19971015)16:19<2157::AID-SIM653>3.0.CO;2-X"},{"key":"S0950268816003150_ref30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1164\/rccm.201302-0365OC","article-title":"Interferon-gamma release assays and tuberculin skin testing for diagnosis of latent tuberculosis infection in healthcare workers in the United States","volume":"189","author":"Dorman","year":"2014","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"S0950268816003150_ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058202"},{"key":"S0950268816003150_ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030494"},{"key":"S0950268816003150_ref15","volume-title":"Statistical Methods for Rates and Proportions","author":"Fleisss","year":"1981"},{"key":"S0950268816003150_ref19","first-page":"498","article-title":"Thinking in three dimensions: a web-based algorithm to aid the interpretation of tuberculin skin test results","volume":"12","author":"Menzies","year":"2008","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268816003150_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62335-7"},{"key":"S0950268816003150_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117428"},{"key":"S0950268816003150_ref1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1703.100947"},{"key":"S0950268816003150_ref2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-1-199401010-00012"},{"key":"S0950268816003150_ref34","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/601737"},{"key":"S0950268816003150_ref7","first-page":"12","article-title":"Tuberculosis in health personnel, Colombia, 2008 to 2012. Bogot\u00e1, Colombia:","volume":"2","author":"Castillo","year":"2013","journal-title":"National Epidemiological Fortnightly Report"},{"key":"S0950268816003150_ref22","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01245-2015"},{"key":"S0950268816003150_ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12995-015-0044-y"},{"key":"S0950268816003150_ref37","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0680"},{"key":"S0950268816003150_ref13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1086\/338149","article-title":"Evolution and current use of the tuberculin test","volume":"34","author":"Lee","year":"2002","journal-title":"Clinical Infectious Diseases"},{"key":"S0950268816003150_ref12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200811-1704OC"},{"key":"S0950268816003150_ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-67"},{"key":"S0950268816003150_ref11","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.156210"},{"key":"S0950268816003150_ref3","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01910-2015"},{"key":"S0950268816003150_ref10","first-page":"312","article-title":"National shortage of purified-protein derivative tuberculin products","volume":"62","year":"2013","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268816003150_ref18","first-page":"895","article-title":"Improving the estimation of tuberculosis infection prevalence using T-cell-based assay and mixture models","volume":"12","author":"Pai","year":"2008","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268816003150_ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008257"},{"key":"S0950268816003150_ref36","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814003537"},{"key":"S0950268816003150_ref29","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00034-13"},{"key":"S0950268816003150_ref21","volume-title":"Guidelines on the Management of Latent Tuberculosis Infection","year":"2015"},{"key":"S0950268816003150_ref24","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.150"},{"key":"S0950268816003150_ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001012"},{"key":"S0950268816003150_ref32","first-page":"1","article-title":"Updated guidelines for using interferon gamma release assays to detect Mycobacterium tuberculosis infection \u2013 United States, 2010","volume":"59","author":"Mazurek","year":"2010","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268816003150_ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043014"},{"key":"S0950268816003150_ref17","article-title":"Understanding the effects of conditional dependence in research studies involving imperfect diagnostic tests","author":"Wang","year":"2016","journal-title":"Statistics in Medicine"},{"key":"S0950268816003150_ref35","article-title":"Risk of tuberculosis infection and disease associated with work in health care settings","volume":"11","author":"Menzies","year":"2007","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"S0950268816003150_ref28","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2746"},{"key":"S0950268816003150_ref14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9801120"},{"key":"S0950268816003150_ref6","first-page":"12","article-title":"Monitoring delays in diagnosis of pulmonary tuberculosis in eight cities in Colombia","volume":"39","author":"Rodriguez","year":"2016","journal-title":"Pan American Journal of Public Health"},{"key":"S0950268816003150_ref5","article-title":"Health Secretary Medell\u00edn. Epidemiological profile tuberculosis Medell\u00edn 2013","author":"Almanza","journal-title":"Epidemiological Bulletin"},{"key":"S0950268816003150_ref20","unstructured":"Colombia. Ministry of Health and Social Protection. Adjustments to the current guidelines for the programmatic management of Tuberculosis and Leprosy: Technical Annex 3: Guidelines and recommendations of the Advisory National Committee for the diagnosis and treatment of latent tuberculosis infection 2015 (https:\/\/www.minsalud.gov.co\/sites\/rid\/Lists\/BibliotecaDigital\/RIDE\/DE\/DIJ\/circular-externa-0007-de-2015.pdf)."}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268816003150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:09:52Z","timestamp":1658362192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268816003150\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,9]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0950268816003150"],"URL":"https:\/\/doi.org\/10.1017\/s0950268816003150","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,9]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}