{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:36:01Z","timestamp":1773884161346,"version":"3.50.1"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Childhood varicella vaccination has not yet been introduced in the UK. To inform decision-making about future vaccine programmes, data on the burden of varicella in general practice over a 10-year period (01\/01\/2005\u201331\/12\/2014) was calculated by age and ethnicity, using anonymised data from &gt;8 million individuals in the Clinical Practice Research Datalink. Varicella consultations peaked at 20 603 in 2007, then decreased annually in all age groups to 11 243 in 2014. Each year, consultation rates were common among infants, were highest among 1\u20133 year olds (61\u00b72 consultations\/1000 person-years in 2007, 39\u00b77\/1000 person-years in 2014) and then fell with increasing age to &lt;1\u00b70\/1000 person-years at ages \u2a7e20 years. Varicella acquisition appeared to be delayed in some ethnic groups, with lower consultation rates for children aged &lt;3 years but increased rates for older children and adults aged \u2a7d40 years among those of black African, Afro-Caribbean, South Asian or other Asian ethnicity. Decreasing general practice consultation rates over time could reflect changes in healthcare utilisation, with patients seeking care in alternative settings such as Accident and Emergency Departments, although current data prevent full assessment of this. Availability of data on varicella diagnoses across all health settings would enable estimation of the total healthcare burden due to varicella and the cost-effectiveness of introducing varicella vaccination.<\/jats:p>","DOI":"10.1017\/s0950268817001649","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T09:05:02Z","timestamp":1504083902000},"page":"2678-2682","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["Trends in the burden of varicella in UK general practice"],"prefix":"10.1017","volume":"145","author":[{"given":"J. L.","family":"WALKER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"ANDREWS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"MATHUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"SMEETH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"THOMAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"S0950268817001649_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1115"},{"key":"S0950268817001649_ref3","unstructured":"Public Health England. Varicella: The Green Book Chapter 34. August 2015. Available from https:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/456562\/Green_Book_Chapter_34_v3_0.pdf. Accessed 2 January 2017."},{"key":"S0950268817001649_ref4","unstructured":"Joint Committee on Vaccination and Immunisation. Joint Committee on Vaccination and Immunisation Statement on varicella and herpes zoster vaccines 29\u00b703\u00b710. Available from http:\/\/webarchive.nationalarchives.gov.uk\/20120907090205\/http:\/\/:\/www.dh.gov.uk\/prod_consum_dh\/groups\/dh_digitalassets\/@dh\/@ab\/documents\/digitalasset\/dh_133599.pdf. Accessed 2 January 2017."},{"key":"S0950268817001649_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268801005921"},{"key":"S0950268817001649_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.07.036"},{"key":"S0950268817001649_ref9","unstructured":"British Medical Association. Ethnicity and first language recording. British Medical Association, 2012. Available from https:\/\/www.bma.org.uk\/advice\/employment\/contracts\/gp-partner-contracts\/desethnicity. Accessed 2 January 2017."},{"key":"S0950268817001649_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv098"},{"key":"S0950268817001649_ref2","doi-asserted-by":"publisher","DOI":"10.2174\/157339609791317315"},{"key":"S0950268817001649_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39609.449676.25"},{"key":"S0950268817001649_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.01.005"},{"key":"S0950268817001649_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdt116"},{"key":"S0950268817001649_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.05.008"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268817001649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T22:52:37Z","timestamp":1555455157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268817001649\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,30]]},"references-count":12,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0950268817001649"],"URL":"https:\/\/doi.org\/10.1017\/s0950268817001649","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,30]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2017\u00a0This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}