{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:23:26Z","timestamp":1790310206757,"version":"4.1.0"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"14","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Vitamin D could modulate pathways leading to dengue hemorrhagic fever\/dengue shock syndrome (DHF\/DSS). We examined the associations of serum total 25-hydroxy vitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations in patients with uncomplicated dengue fever (DF) with risk of progression to DHF\/DSS. In a case\u2013control study nested in a cohort of DF patients who were followed during the acute episode in Bucaramanga, Colombia, we compared 25(OH)D and VDBP at onset of fever between 110 cases who progressed to DHF\/DSS and 235 DF controls who did not progress. 25(OH)D concentrations were also compared between the acute sample and a sample collected &gt;1 year post-convalescence in a subgroup. Compared with 25(OH)D \u2a7e75 nmol\/l, adjusted odds ratios (95% CI) for progression were 0\u00b744 (0\u00b722\u20130\u00b788) and 0\u00b713 (0\u00b702\u20131\u00b705) for 50 to 75 nmol\/l (vitamin D insufficiency) and &lt;50 nmol\/l (vitamin D deficiency), respectively (<jats:italic>P<\/jats:italic>, trend = 0\u00b7003). Mean 25(OH)D concentrations were much lower post-convalescence compared with the acute episode, regardless of case status. Compared with controls, mean VDBP was non-significantly lower in cases. We conclude that low serum 25(OH)D concentrations in DF patients predict decreased odds of progression to DHF\/DSS.<\/jats:p>","DOI":"10.1017\/s0950268817002059","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T06:45:26Z","timestamp":1505371526000},"page":"2961-2970","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":33,"title":["Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever\/dengue shock syndrome"],"prefix":"10.1017","volume":"145","author":[{"given":"E.","family":"VILLAMOR","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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