{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T11:39:07Z","timestamp":1725017947487},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The high rate of chronic hepatitis C (CHC) was one of the key issues of global public health concern. Interferon (<jats:italic>IFN<\/jats:italic>)<jats:italic>-\u03bb<\/jats:italic>relevant genes were in the antiviral treatment pathway, not only influenced hepatitis C virus (HCV) spontaneous clearance, but also affected the IFN-mediated viral clearance. The aim of this study was to identify the association of interleukin 28B (<jats:italic>IL28B<\/jats:italic>), myxovirus resistance A (<jats:italic>MxA<\/jats:italic>) gene polymorphisms with HCV spontaneous clearance and therapeutic response in Chinese CHC patients.<jats:italic>IL28B<\/jats:italic>and<jats:italic>MxA<\/jats:italic>gene genotypes were detected among 231 CHC carriers, 428 subjects with HCV spontaneous clearance and 662 CHC patients with pegylated IFN-<jats:italic>\u03b1<\/jats:italic>and ribavirin (pegIFN-<jats:italic>\u03b1<\/jats:italic>\/RBV) treatment. Patients with<jats:italic>MxA<\/jats:italic>rs2071430 TT genotype were more likely to develop HCV infection chronicity (additive model: odds ratio (OR) 1.22, 95% confidence interval (CI) 1.01\u20131.48,<jats:italic>P<\/jats:italic>= 0.042).<jats:italic>IL28B<\/jats:italic>rs1298075 variant genotypes (additive model: OR 0.58, 95% CI 0.34\u20130.98,<jats:italic>P<\/jats:italic>= 0.040) and<jats:italic>MxA<\/jats:italic>rs17000900 variant genotypes (additive model: OR 0.54, 95% CI 0.30\u20130.99,<jats:italic>P<\/jats:italic>= 0.048) were less likely to achieve a sustained virological response. The life table indicated that patients with<jats:italic>IL28B<\/jats:italic>rs1298075 AG genotype were slower to achieve a viral load &lt;500 copies\/ml (<jats:italic>P<\/jats:italic>= 0.018). During the treatment, the downward trend in viral load was different among each<jats:italic>IL28B<\/jats:italic>rs1298075 genotype, especially in subgroup with a baseline HCV-RNA &gt;10<jats:sup>6<\/jats:sup>copies\/ml (all<jats:italic>P<\/jats:italic>&lt; 0.05). This study illustrated that the carriage of<jats:italic>IL28B<\/jats:italic>rs12980275 AA had a positive effect on treatment response to pegIFN-<jats:italic>\u03b1<\/jats:italic>\/RBV among Chinese CHC patients.<\/jats:p>","DOI":"10.1017\/s0950268817002928","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T11:24:40Z","timestamp":1513941880000},"page":"379-385","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Influence of<i>IL28B<\/i>and<i>MxA<\/i>gene polymorphisms on HCV clearance in Han Chinese population"],"prefix":"10.1017","volume":"146","author":[{"given":"Feng","family":"Zang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haozhi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueshan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongbin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"S0950268817002928_ref1","first-page":"195","article-title":"Natural 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