{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T15:10:02Z","timestamp":1751296202997,"version":"3.41.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An outbreak of enterohaemorrhagic<jats:italic>Escherichia coli<\/jats:italic>O157 occurred in multiple prefectures of Japan in November 2009. We conducted two case\u2013control studies with trace-back and trace-forward investigations to determine the source. The case definition was met by 21 individuals; 14 (66.7%) were hospitalised, but no haemolytic uraemic syndrome, acute encephalopathy or deaths occurred. Median age was 23 (range 12\u201348) years and 14 cases were male (66.7%). No significant associations with food were found in a case\u2013control study by local public health centres, but our matched case\u2013control study using Internet surveys found that beef hanging tender (or hanger steak), derived from the diaphragm of the cattle, was significantly associated with illness (odds ratio = 15.77; 95% confidence interval, 2.00\u2013124.11). Pulsed-field gel electrophoresis analysis of isolates from patients and the suspected food showed five different patterns: two in faecal and food samples, and another three in patient faecal samples only, although there were epidemiological links to the meat consumed at the restaurants. Trace-back investigation implicated a common food processing company from outside Japan. Examination of the logistics of the meat processing company suggested that contamination did not occur in Japan. We concluded that the source of the outbreak was imported hanging tender. This investigation revealed that Internet surveys could be useful for outbreak investigations.<\/jats:p>","DOI":"10.1017\/s0950268817003132","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:41:40Z","timestamp":1517791300000},"page":"450-457","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Web survey-based selection of controls for epidemiological analyses of a multi-prefectural outbreak of enterohaemorrhagic<i>Escherichia coli<\/i>O157 in Japan associated with consumption of self-grilled beef hanging tender"],"prefix":"10.1017","volume":"146","author":[{"given":"Y.","family":"Yahata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Odaira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Matsuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Shuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Toyozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Terajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sunagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"S0950268817003132_ref22","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814003641"},{"key":"S0950268817003132_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114359"},{"key":"S0950268817003132_ref17","doi-asserted-by":"publisher","DOI":"10.1086\/597399"},{"key":"S0950268817003132_ref10","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6443a4"},{"key":"S0950268817003132_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198303243081203"},{"key":"S0950268817003132_ref2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08921209"},{"key":"S0950268817003132_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268816000509"},{"key":"S0950268817003132_ref14","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2013.1726"},{"key":"S0950268817003132_ref5","first-page":"249","article-title":"Outbreak of Escherichia coli O157:H7 infection \u2013 Georgia and Tennessee, June 1995","volume":"45","year":"1996","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268817003132_ref13","doi-asserted-by":"publisher","DOI":"10.1086\/421088"},{"key":"S0950268817003132_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir831"},{"key":"S0950268817003132_ref23","unstructured":"WHO Collaborating Centre for Reference and Research on Escherichia and Klebsiella (2017) Identification of three vtx1 and seven vtx2 subtypes of Verocytotoxin encoding genes of Escherichia coli by conventional PCR amplification Version 6. 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