{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:02:57Z","timestamp":1778900577732,"version":"3.51.4"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The main objective of our study was to describe the epidemiological and microbiological features of an oligoclonal hospital-wide outbreak caused by OXA-48-producing <jats:italic>Enterobacteriaceae<\/jats:italic> (OXA-48-PE). OXA-48 is a carbapenemase belonging to Ambler class D <jats:italic>beta<\/jats:italic>-lactamases, identified frequently in the Mediterranean and Southern European countries, and associated with several <jats:italic>Enterobacteriaceae<\/jats:italic> species. An outbreak of OXA-48-PE with a complex epidemic pattern was detected in January 2011. Initial control measures included contact precautions and the reinforcement of infection control practices, but despite all efforts made, the epidemiological situation hardly changed and new measures were implemented during 2013. An observational retrospective study was performed to describe the main features of the outbreak and to analyse the cumulative incidence (CI) trends. Eight hundred and 16 patients colonised or infected by OXA-48-PE were identified during the 2-year period (January 2013\u2013December 2014), female 46%, mean age (<jats:sc>s.d.<\/jats:sc>), 71.6 (15.2). The samples isolated in the incident cases were rectal swabs (80%), urine samples (10.7%), blood samples (2.8%) and other clinical samples (6.6%). The most frequent OXA-48-PE was <jats:italic>Klebsiella pneumoniae<\/jats:italic>. Eleven different clones were identified, but <jats:italic>K. pneumoniae<\/jats:italic> sequence types 11 and 405 were predominant: ST11 (64.2%) and ST405 (29.3%). OXA-48-PE CI trend suffered a statistically significant change in August 2013, which continued the following months. Though we could not eradicate the outbreak, we observed a statistically significant drop in CI after an intervention for OXA-48-PE control, based on patient cohort, active surveillance, electronic alerts and reinforcement of infection control measures in a tertiary hospital.<\/jats:p>","DOI":"10.1017\/s0950268818000249","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T16:15:00Z","timestamp":1519143300000},"page":"656-662","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Epidemiology and control measures of an OXA-48-producing <i>Enterobacteriaceae<\/i> hospital-wide oligoclonal outbreak"],"prefix":"10.1017","volume":"146","author":[{"given":"V.","family":"P\u00e9rez-Blanco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Redondo-Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ru\u00edz-Carrascoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Pa\u00f1o-Pardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"G\u00f3mez-Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Robustillo-Rodela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Garc\u00eda- Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mingorance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Herruzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"S0950268818000249_ref23","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00261-16"},{"key":"S0950268818000249_ref25","article-title":"Carbapenem-resistant gram-negative bacteria - analysis of the data obtained through a mandatory reporting system in the Rhine-Main region, Germany, 2012-2015","volume":"11","author":"Heudorf","year":"2016","journal-title":"GMS Hygiene and Infection Control"},{"key":"S0950268818000249_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.03.005"},{"key":"S0950268818000249_ref5","unstructured":"Centers for Disease Control (2012) Guidance for control of carbapenem-resistant Enterobacteriaceae (CRE): 2012 CRE Toolkit. Available at https:\/\/www.cdc.gov\/hai\/pdfs\/cre\/CRE-guidance-508.pdf. (Accesed 29 November 2012)."},{"key":"S0950268818000249_ref13","doi-asserted-by":"publisher","DOI":"10.1086\/596734"},{"key":"S0950268818000249_ref3","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2016.032"},{"key":"S0950268818000249_ref8","unstructured":"European Centre for Disease Prevention and Control. (2014) Antimicrobial resistance surveillance in Europe 2013. Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). ECDC."},{"key":"S0950268818000249_ref6","volume-title":"Carbapenemase-Producing Bacteria in Europe: Interim Results From the European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Project","year":"2013"},{"key":"S0950268818000249_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit795"},{"key":"S0950268818000249_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.02.019"},{"key":"S0950268818000249_ref7","unstructured":"Public Health England (2013) Acute trust toolkit for the early detection, management and control of carbapenemase-producing Enterobacteriaceae. 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