{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:52:21Z","timestamp":1788173541562,"version":"build-2803163510"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Toll-like receptor 2 (TLR2) is a key member of TLRs, which is crucial in the initial inflammatory response against bacteria. TLR2, is also the initial barrier against bacterial infection and plays an important role in recognising a variety of bacterial lipoproteins. Several studies have been performed to investigate the TLR2 + 2477G\/A polymorphism and bacterial meningitis susceptibility. Unfortunately, the results of previous studies were controversial. Therefore, we performed a meta-analysis to derive a more precise estimation of the association. The association between the TLR2 + 2477G\/A polymorphism and bacterial meningitis susceptibility was assessed by odds ratios together with their 95% confidence intervals (CI). Six studies were enrolled in the present meta-analysis. Overall, no significant association between TLR2 + 2477G\/A polymorphism and bacterial meningitis risk were found under allele contrast (A <jats:italic>vs.<\/jats:italic> G: OR = 1.15, 95% CI = 0.93\u20131.43, <jats:italic>P<\/jats:italic> = 0.202), recessive genetic model (AA <jats:italic>vs.<\/jats:italic> AG\/GG: OR = 1.12, 95% CI = 0.90\u20131.41, <jats:italic>P<\/jats:italic> = 0.313). The significant association was found between TLR2 + 2477G\/A polymorphism and pneumococcal meningitis risk under allele contrast (A <jats:italic>vs.<\/jats:italic> G: OR = 1.54, 95% CI = 1.01\u20132.36, <jats:italic>P<\/jats:italic> = 0.046), recessive genetic model (AA <jats:italic>vs.<\/jats:italic> AG\/GG: OR = 1.63, 95% CI = 1.03\u20132.57, <jats:italic>P<\/jats:italic> = 0.035). We conclude that TLR2 + 2477G\/A polymorphism is not associated with meningococcal meningitis risk but contributes an increased risk of pneumococcal meningitis.<\/jats:p>","DOI":"10.1017\/s0950268818000298","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T06:46:06Z","timestamp":1519022766000},"page":"642-647","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":22,"title":["Association between TLR2 + 2477G\/A polymorphism and bacterial meningitis: a meta-analysis"],"prefix":"10.1017","volume":"146","author":[{"given":"Xiaochun","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhou","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youtao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"S0950268818000298_ref20","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.11.6398-6401.2000"},{"key":"S0950268818000298_ref19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.375493"},{"key":"S0950268818000298_ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035837"},{"key":"S0950268818000298_ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064252"},{"key":"S0950268818000298_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2013.08.006"},{"key":"S0950268818000298_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.04.024"},{"key":"S0950268818000298_ref12","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"S0950268818000298_ref10","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"Journal of the National Cancer Institute"},{"key":"S0950268818000298_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"S0950268818000298_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.05.012"},{"key":"S0950268818000298_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.08.009"},{"key":"S0950268818000298_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-007-0081-4"},{"key":"S0950268818000298_ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-232"},{"key":"S0950268818000298_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2008.07.004"},{"key":"S0950268818000298_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"S0950268818000298_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-016-0907-x"},{"key":"S0950268818000298_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70045-1"},{"key":"S0950268818000298_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"S0950268818000298_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3282f88b5d"},{"key":"S0950268818000298_ref15","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00042-13"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268818000298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T04:44:07Z","timestamp":1580359447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268818000298\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,19]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0950268818000298"],"URL":"https:\/\/doi.org\/10.1017\/s0950268818000298","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,19]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2018\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}