{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:15:48Z","timestamp":1790154948385,"version":"4.0.1"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"15","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over the recent years, potential associations between <jats:italic>Toxoplasma gondii<\/jats:italic> (<jats:italic>T. gondii<\/jats:italic>) infection and cancer risk have attracted a lot of attention. Nevertheless, the association between <jats:italic>T. gondii<\/jats:italic> infection and oral cancer remains relatively unexplored. We performed a case\u2013control study of 861 oral cancer patients and 861 control subjects from eastern China with the aim to detect antibodies to <jats:italic>T. gondii<\/jats:italic> by enzyme-linked immunosorbent assay (ELISA) in these patients. The results showed that oral cancer patients (21.72%, 187\/861) had a significantly higher seroprevalence than control subjects (8.25%, 71\/861) (<jats:italic>P<\/jats:italic> &lt; 0.001). Among them, 144 (16.72%) oral cancer patients and 71 (8.25%) control subjects were positive for IgG antibodies to <jats:italic>T. gondii<\/jats:italic>, while 54 (6.27%) oral cancer patients and 9 (1.05%) controls were positive for IgM antibodies to <jats:italic>T. gondii<\/jats:italic>. In addition, multiple logistic analysis showed that <jats:italic>T. gondii<\/jats:italic> infection in oral cancer patients was associated with blood transfusion history, keeping cats at home, and oyster consumption. To our knowledge, this is the first study that provided a serological evidence of an association between <jats:italic>T. gondii<\/jats:italic> infection and oral cancer patients. However, further studies are necessary to elucidate the role of <jats:italic>T. gondii<\/jats:italic> in oral cancer patients.<\/jats:p>","DOI":"10.1017\/s0950268818001978","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:36:20Z","timestamp":1531442180000},"page":"1891-1895","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Seroprevalence and risk factors of <i>Toxoplasma gondii<\/i> infection in oral cancer patients in China: a case\u2013control prospective study"],"prefix":"10.1017","volume":"146","author":[{"given":"N.","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Y.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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