{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T01:37:25Z","timestamp":1770082645902,"version":"3.49.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"unspecified","delay-in-days":59,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to determine the frequency of multiple type human papillomavirus (HPV) infections, and whether any types are involved in multiple HPV-type infections (mHPV) more or less frequently than expected. From January 2012 to February 2018, 2848 cervico-vaginal swabs were analysed in the UOC Microbiology and Virology of Policlinico of Bari, Italy. HPV DNA detection was performed using initially nested-polymerase chain reaction (PCR) and subsequently multiplex real-time PCR assay. 1357\/2848 samples (47.65%) were HPV DNA positive and 694\/1357 (51.14%) showed mHPVs. The median number of mHPVs was 2 (interquartile range: 2\u20133). HPV-types more frequently detected were 42 (9.97%), 16 (8.92%), 53 (7.23%) and 31 (7.16%). Each detected HPV-type was involved in mHPVs in more than 50% of cases. Statistical analysis showed significant associations for all HPV-types except for 33, 43, 51, 58 and 82 HPV-types. The major number of significant pairwise associations were detected for the types 42 and 70. Only positive associations were detected. Further data are necessary to evaluate the clinical impact of the single combinations.<\/jats:p>","DOI":"10.1017\/s0950268818003539","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T10:32:39Z","timestamp":1551436359000},"source":"Crossref","is-referenced-by-count":17,"title":["Epidemiological evaluation of human papillomavirus genotypes and their associations in multiple infections"],"prefix":"10.1017","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-3388","authenticated-orcid":false,"given":"Raffaele","family":"Del Prete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Ronga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Magrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Addati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Abbasciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Di Carlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Miragliotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"S0950268818003539_ref30","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.57.1.68"},{"key":"S0950268818003539_ref36","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600688"},{"key":"S0950268818003539_ref9","doi-asserted-by":"publisher","DOI":"10.1086\/497342"},{"key":"S0950268818003539_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.01.011"},{"key":"S0950268818003539_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq131"},{"key":"S0950268818003539_ref16","doi-asserted-by":"publisher","DOI":"10.1086\/324579"},{"key":"S0950268818003539_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf013"},{"key":"S0950268818003539_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir717"},{"key":"S0950268818003539_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21528"},{"key":"S0950268818003539_ref24","volume-title":"A Language and Environment for Statistical Computing: The R Foundation for Statistical Computing","year":"2016"},{"key":"S0950268818003539_ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01887.x"},{"key":"S0950268818003539_ref40","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-11-11"},{"key":"S0950268818003539_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq356"},{"key":"S0950268818003539_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24075"},{"key":"S0950268818003539_ref33","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31829e9fb4"},{"key":"S0950268818003539_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq146"},{"key":"S0950268818003539_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.03.552"},{"key":"S0950268818003539_ref28","doi-asserted-by":"publisher","DOI":"10.1086\/428850"},{"key":"S0950268818003539_ref29","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.4.244"},{"key":"S0950268818003539_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70360-2"},{"key":"S0950268818003539_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04956-4"},{"key":"S0950268818003539_ref22","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0465"},{"key":"S0950268818003539_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir652"},{"key":"S0950268818003539_ref26","first-page":"45","article-title":"High-risk and multiple human papillomavirus infections associated with cervical abnormalities in Japanese women","volume":"10","author":"Sasagawa","year":"2001","journal-title":"Cancer Epidemiology Biomarkers and Prevention"},{"key":"S0950268818003539_ref17","doi-asserted-by":"publisher","DOI":"10.1086\/444391"},{"key":"S0950268818003539_ref15","first-page":"247","article-title":"Prevalence, genotype distribution and temporal dynamics of human papillomavirus infection in a population in southern Italy","volume":"25","author":"Del Prete","year":"2017","journal-title":"Infezioni in Medicina"},{"key":"S0950268818003539_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20805"},{"key":"S0950268818003539_ref32","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0129"},{"key":"S0950268818003539_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090710"},{"key":"S0950268818003539_ref1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0983"},{"key":"S0950268818003539_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019894"},{"key":"S0950268818003539_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.03.047"},{"key":"S0950268818003539_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.02.013"},{"key":"S0950268818003539_ref13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.30699\/ijp.2017.24229","article-title":"Cervical cancer and genital infections: assessment of performance and validation in human papillomavirus genotyping assays in Iran, its neighbor countries and Persian Gulf areas","volume":"12","author":"Sohrabi","year":"2017","journal-title":"Iranian Journal of Pathology"},{"key":"S0950268818003539_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23143"},{"key":"S0950268818003539_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq139"},{"key":"S0950268818003539_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.10.010"},{"key":"S0950268818003539_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1085"},{"key":"S0950268818003539_ref38","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.8.813"},{"key":"S0950268818003539_ref39","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2018.72.26-30"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268818003539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T00:43:57Z","timestamp":1606610637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268818003539\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":40,"alternative-id":["S0950268818003539"],"URL":"https:\/\/doi.org\/10.1017\/s0950268818003539","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"article-number":"e132"}}