{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:06:01Z","timestamp":1790406361741,"version":"4.1.0"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"unspecified","delay-in-days":59,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our purpose was to describe the clinical, epidemiological and laboratory characteristics of patients hospitalised with acute Q fever in an endemic area of Israel. We conducted a historical cohort study of all patients hospitalised with a definite diagnosis of acute Q fever, and compared them to patients suspected to have acute Q fever, but diagnosis was ruled out. A total of 38 patients had a definitive diagnosis, 47% occurred during the autumn and winter seasons, only 18% lived in rural regions. Leucopaenia and thrombocytopaenia were uncommon (16% and 18%, respectively), but mild hepatitis was common (mean aspartate aminotransferase 76 U\/l, mean alanine aminotransferase 81 U\/l). We compared them with 74 patients in which acute Q fever was ruled out, and found that these parameters were not significantly different. Patients with acute Q fever had a shorter hospitalisation and they were treated more often with doxycycline than those without acute Q fever (6.4<jats:italic>vs<\/jats:italic>. 14 days,<jats:italic>P<\/jats:italic>= 0.007, 71%<jats:italic>vs<\/jats:italic>. 38%,<jats:italic>P<\/jats:italic>= 0.001, respectively). In conclusion, acute Q fever can manifest as an unspecified febrile illness, with no seasonality. We suggest that in endemic areas, Q fever should be considered in the differential diagnosis in any febrile patient with risk factors for a persistent infection.<\/jats:p>","DOI":"10.1017\/s0950268818003576","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T10:32:38Z","timestamp":1551436358000},"source":"Crossref","is-referenced-by-count":8,"title":["Epidemiological, clinical and laboratory characteristics of acute Q fever in an endemic area in Israel, 2006\u20132016"],"prefix":"10.1017","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4608-2040","authenticated-orcid":false,"given":"S.","family":"Reisfeld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hasadia Mhamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"S0950268818003576_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.06.016"},{"key":"S0950268818003576_ref8","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/JCM.22.4.484-487.1985","article-title":"Immunoglobulin responses in acute Q fever","volume":"22","author":"Dupuis","year":"1985","journal-title":"Journal of Clinical Microbiology"},{"key":"S0950268818003576_ref5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s10096-003-1095-z","article-title":"Comparative incidence of acute Q fever in two ethnic groups in Israel","volume":"23","author":"Bishara","year":"2004","journal-title":"European Journal of Clinical Microbiology and Infectious Diseases"},{"key":"S0950268818003576_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68266-4"},{"key":"S0950268818003576_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268812000118"},{"key":"S0950268818003576_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.04.024"},{"key":"S0950268818003576_ref1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.518"},{"key":"S0950268818003576_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-010-0052-x"},{"key":"S0950268818003576_ref6","first-page":"337","article-title":"Acute Q fever in Israel: clinical and laboratory study of 100 hospitalized patients","volume":"8","author":"Ergas","year":"2006","journal-title":"Israel Medical Association Journal"},{"key":"S0950268818003576_ref7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1128\/CDLI.1.2.189-196.1994","article-title":"Q fever serology: cutoff determination for microimmunofluorescence","volume":"1","author":"Dupont","year":"1994","journal-title":"Clinical and Diagnostic Laboratory Immunology"},{"key":"S0950268818003576_ref9","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0164"},{"key":"S0950268818003576_ref11","doi-asserted-by":"publisher","DOI":"10.1086\/652442"},{"key":"S0950268818003576_ref12","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00045-16"},{"key":"S0950268818003576_ref13","doi-asserted-by":"publisher","DOI":"10.1086\/321889"},{"key":"S0950268818003576_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit419"},{"key":"S0950268818003576_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.10.010"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268818003576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T00:43:56Z","timestamp":1606610636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268818003576\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":16,"alternative-id":["S0950268818003576"],"URL":"https:\/\/doi.org\/10.1017\/s0950268818003576","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"article-number":"e131"}}