{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:59:33Z","timestamp":1792004373478,"version":"4.4.0"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"unspecified","delay-in-days":64,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carbapenem-resistant<jats:italic>Enterobacteriaceae<\/jats:italic>conferred by New Delhi metallo-b-lactamase (NDM-1) resistance mechanism are endemic in India and Southeast Asia. An understanding of risk factors for NDM-1 infections is necessary to guide prevention strategies. We performed a retrospective case-control study of patients admitted at Christian Medical College Hospital, Vellore, India between May 2010 and August 2014 with<jats:italic>Klebsiella pneumoniae<\/jats:italic>blood stream infection (BSI). We compared patients with BSI caused by NDM-1 producing strains to two control groups: BSI with other multidrug resistant (MDR) strains and BSI with pan-susceptible strains. The study groups were assessed for risk factors for the outcomes: (1) infection with any MDR strain compared to pan-susceptible; and, (2) infection with NDM-1 strain as compared with other MDR and (3) Mortality. A total of 101 patients with BSI with NDM-1 producing<jats:italic>Klebsiella pneumoniae<\/jats:italic>were matched to two groups of controls: 112 with non-NDM-1 MDR strains and 101 with pan-susceptible strains. Medical (OR 10.4) and neonatal (OR 0.7) ICU admission, central venous catheter placement (CVC, OR 7.4) predicted MDR BSI. Prior carbapenem use (OR 8.4) and CVC (OR 4.8) predicted acquisition of an NDM-1 strain. Significant predictors for mortality included ICU stay (OR 3.0), mechanical ventilation (OR 3.2), female gender (OR 2.2), diabetes (OR 0.4). CVC placement, prior carbapenem use and ICU admission were significantly associated with BSI with NDM-1 producing and other MDR strains.<\/jats:p>","DOI":"10.1017\/s0950268819000256","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T02:10:14Z","timestamp":1551838214000},"source":"Crossref","is-referenced-by-count":51,"title":["Risk factors and epidemiologic predictors of blood stream infections with New Delhi Metallo-b-lactamase (NDM-1) producing<i>Enterobacteriaceae<\/i>"],"prefix":"10.1017","volume":"147","author":[{"given":"B. M.","family":"Snyder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-6955","authenticated-orcid":false,"given":"B. T.","family":"Montague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Anandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Madabhushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Pragasam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. P.","family":"Verghese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-4257","authenticated-orcid":false,"given":"V.","family":"Balaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A. F.","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"S0950268819000256_ref27","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01946-13"},{"key":"S0950268819000256_ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-016-0763-y"},{"key":"S0950268819000256_ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01859"},{"key":"S0950268819000256_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2016.10.008"},{"key":"S0950268819000256_ref22","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.1261"},{"key":"S0950268819000256_ref21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05961-11"},{"key":"S0950268819000256_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl481"},{"key":"S0950268819000256_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp498"},{"key":"S0950268819000256_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.12.002"},{"key":"S0950268819000256_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.02.001"},{"key":"S0950268819000256_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123337"},{"key":"S0950268819000256_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1222343"},{"key":"S0950268819000256_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-017-1012-8"},{"key":"S0950268819000256_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00585-11"},{"key":"S0950268819000256_ref4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00774-09"},{"key":"S0950268819000256_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw741"},{"key":"S0950268819000256_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001499"},{"key":"S0950268819000256_ref26","first-page":"297","article-title":"Impact of the New Delhi metallo-beta-lactamase on beta-lactam antibiotics","volume":"8","author":"Zmarlicka","year":"2015","journal-title":"Infection and Drug Resistance"},{"key":"S0950268819000256_ref13","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.067744-0"},{"key":"S0950268819000256_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2710-0"},{"key":"S0950268819000256_ref16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.1151-1161.2001"},{"key":"S0950268819000256_ref1","doi-asserted-by":"publisher","DOI":"10.1086\/592412"},{"key":"S0950268819000256_ref20","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00022-11"},{"key":"S0950268819000256_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir720"},{"key":"S0950268819000256_ref3","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2017.1340128"},{"key":"S0950268819000256_ref8","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/QCO.0000000000000495","article-title":"Combination versus monotherapy for the treatment of infections due to carbapenem-resistant enterobacteriaceae","volume":"31","author":"Carrara","year":"2018","journal-title":"Current Opinion in Infectious Diseases"},{"key":"S0950268819000256_ref9","first-page":"Dc08","article-title":"Risk factor analysis in clinical isolates of ESBL and MBL (Including NDM-1) producing Escherichia coli and Klebsiella species in a tertiary care hospital","volume":"9","author":"Kumar","year":"2015","journal-title":"Journal of Clinical and Diagnostic Research: JCDR"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268819000256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T23:14:41Z","timestamp":1574205281000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268819000256\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":27,"alternative-id":["S0950268819000256"],"URL":"https:\/\/doi.org\/10.1017\/s0950268819000256","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"article-number":"e137"}}