{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:04:22Z","timestamp":1790193862531,"version":"4.1.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"unspecified","delay-in-days":241,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maternal systemic inflammation during pregnancy may restrict embryo\u2212fetal growth, but the extent of this effect remains poorly established in undernourished populations. In a cohort of 653 maternal\u2212newborn dyads participating in a multi-armed, micronutrient supplementation trial in southern Nepal, we investigated associations between maternal inflammation, assessed by serum<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>-acid glycoprotein and C-reactive protein, in the first and third trimesters of pregnancy, and newborn weight, length and head and chest circumferences. Median (IQR) maternal concentrations in<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>-acid glycoprotein and C-reactive protein in the first and third trimesters were 0.65 (0.53\u20130.76) and 0.40 (0.33\u20130.50) g\/l, and 0.56 (0.25\u20131.54) and 1.07 (0.43\u20132.32) mg\/l, respectively.<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>-acid glycoprotein was inversely associated with birth size: weight, length, head circumference and chest circumference were lower by 116 g (<jats:italic>P<\/jats:italic>= 2.3 \u00d7 10<jats:sup>\u22126<\/jats:sup>), and 0.45 (<jats:italic>P<\/jats:italic>= 3.1 \u00d7 10<jats:sup>\u22125<\/jats:sup>), 0.18 (<jats:italic>P<\/jats:italic>= 0.0191) and 0.48 (<jats:italic>P<\/jats:italic>= 1.7 \u00d7 10<jats:sup>\u22127<\/jats:sup>) cm, respectively, per 50% increase in<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>-acid glycoprotein averaged across both trimesters. Adjustment for maternal age, parity, gestational age, nutritional and socio-economic status and daily micronutrient supplementation failed to alter any association. Serum C-reactive protein concentration was largely unassociated with newborn size. In rural Nepal, birth size was inversely associated with low-grade, chronic inflammation during pregnancy as indicated by serum<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>-acid glycoprotein.<\/jats:p>","DOI":"10.1017\/s0950268819001493","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T11:07:26Z","timestamp":1567163246000},"source":"Crossref","is-referenced-by-count":29,"title":["Inflammation throughout pregnancy and fetal growth restriction in rural Nepal"],"prefix":"10.1017","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-1752","authenticated-orcid":false,"given":"Michael W.","family":"Sauder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry J.","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Christian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S. 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