{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:38:28Z","timestamp":1789191508739,"version":"build-2803163510"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"unspecified","delay-in-days":267,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>This study aimed to evaluate the clinical characteristics, risk factors and outcomes of adult patients with candidaemia caused by <jats:italic>C. albicans vs.<\/jats:italic> non-<jats:italic>albicans Candida<\/jats:italic> spp. (NAC). All adult hospitalised cases of candidaemia (2012\u20132017) at a tertiary hospital in Shenyang were included in the retrospective study, and a total of 180 episodes were analysed. <jats:italic>C. parapsilosis<\/jats:italic> was the most frequently isolated species (38.3%), followed by <jats:italic>C. albicans<\/jats:italic> (35.6%), <jats:italic>C. glabrata<\/jats:italic> (13.9%), <jats:italic>C. tropicalis<\/jats:italic> (10%) and others (2.2%). As initial antifungal therapy, 75.0%, 3.9%, 5.6% and 2.2% of patients received fluconazole, caspofungin, micafungin and voriconazole, respectively. Multivariate analyses revealed that total parenteral nutrition was associated with an increased risk of NAC bloodstream infections (BSI) (OR 2.535, 95% CI (1.066\u20136.026)) <jats:italic>vs. C. albicans<\/jats:italic> BSI. Additionally, the presence of a urinary catheter was associated with an increased risk of <jats:italic>C. albicans<\/jats:italic> BSI (OR 2.295 (1.129\u20134.666)) <jats:italic>vs.<\/jats:italic> NAC BSI. Moreover, ICU stay (OR 4.013 (1.476\u201310.906)), renal failure (OR 3.24 (1.084\u20139.683)), thrombocytopaenia (OR 7.171 (2.152\u201323.892)) and <jats:italic>C. albicans<\/jats:italic> (OR 3.629 (1.352\u20139.743)) were independent risk factors for candidaemia-related 30-day mortality, while recent cancer surgery was associated with reduced mortality risk (OR 26.479 (2.550\u2013274.918)). All these factors may provide useful information to select initial empirical antifungal agents.<\/jats:p>","DOI":"10.1017\/s0950268819001638","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T05:48:39Z","timestamp":1569390519000},"source":"Crossref","is-referenced-by-count":38,"title":["Epidemiology, risk factors and outcomes of <i>Candida albicans vs.<\/i> non-<i>albicans<\/i> candidaemia in adult patients in Northeast China"],"prefix":"10.1017","volume":"147","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingpeng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-0081","authenticated-orcid":false,"given":"Rui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"S0950268819001638_ref39","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12039"},{"key":"S0950268819001638_ref38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1407211"},{"key":"S0950268819001638_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2012.08.001"},{"key":"S0950268819001638_ref34","doi-asserted-by":"publisher","DOI":"10.1086\/529435"},{"key":"S0950268819001638_ref32","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/929717"},{"key":"S0950268819001638_ref30","first-page":"153","article-title":"Antibiotics exposure, risk factors, and outcomes with Candida albicans and non-Candida albicans candidemia. 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