{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:19:38Z","timestamp":1777526378034,"version":"3.51.4"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"unspecified","delay-in-days":307,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>In the human population, influenza A viruses are associated with acute respiratory illness and are responsible for millions of deaths annually. Avian and human influenza viruses typically have a different <jats:italic>\u03b1<\/jats:italic>2-3- and <jats:italic>\u03b1<\/jats:italic>2-6-linked sialic acid (SA) binding preference. Only a few amino acid changes in the haemagglutinin on the surface of avian influenza viruses (AIV) can cause a switch from avian to human receptor specificity, and the individuals with pathognostic chronic diseases might be more susceptible to AIV due to the decreased expression level of terminal <jats:italic>\u03b1<\/jats:italic>2-3-linked SA in their saliva. Here, using lectin and virus histochemical staining, we observed the higher expression levels of <jats:italic>\u03b1<\/jats:italic>2-3\/6-linked SA influenza virus receptors in the airway of HBV-transgenic mice compared with that of control mice due to the significant decrease in control mice during ageing, which imply that this is also a risk factor for individuals with pathognostic chronic diseases susceptible to influenza viruses. Our findings will help understand the impact on influenza virus pathogenesis and transmission.<\/jats:p>","DOI":"10.1017\/s0950268819001833","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T04:55:51Z","timestamp":1572843351000},"source":"Crossref","is-referenced-by-count":2,"title":["High expression levels of influenza virus receptors in airway of the HBV-transgenic mice"],"prefix":"10.1017","volume":"147","author":[{"given":"Jiajun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianchun","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1839-3450","authenticated-orcid":false,"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"S0950268819001833_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200900775"},{"key":"S0950268819001833_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23751"},{"key":"S0950268819001833_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis517"},{"key":"S0950268819001833_ref20","doi-asserted-by":"publisher","DOI":"10.1042\/bj3510449"},{"key":"S0950268819001833_ref2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071541"},{"key":"S0950268819001833_ref31","doi-asserted-by":"publisher","DOI":"10.1038\/srep08971"},{"key":"S0950268819001833_ref9","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070248"},{"key":"S0950268819001833_ref44","first-page":"1","article-title":"Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices-United States, 2017\u201318 influenza season","volume":"66","author":"Grohskopf","year":"2017","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268819001833_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/440435a"},{"key":"S0950268819001833_ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01368"},{"key":"S0950268819001833_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11212-0"},{"key":"S0950268819001833_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(83)90150-2"},{"key":"S0950268819001833_ref19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117323"},{"key":"S0950268819001833_ref47","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.110445"},{"key":"S0950268819001833_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1987.tb13387.x"},{"key":"S0950268819001833_ref11","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090949"},{"key":"S0950268819001833_ref15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813172106"},{"key":"S0950268819001833_ref5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308352100"},{"key":"S0950268819001833_ref24","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050695"},{"key":"S0950268819001833_ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.mm6504a4er","article-title":"Prevention and control of seasonal influenza with vaccines recommendations of the advisory committee on immunization practices-United States, 2016\u201317 influenza season","volume":"65","author":"Grohskopf","year":"2016","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268819001833_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(93)90056-S"},{"key":"S0950268819001833_ref8","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1056\/NEJMra052211","article-title":"Avian influenza A (H5N1) infection in humans","volume":"353","author":"Beigel","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"S0950268819001833_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800067248"},{"key":"S0950268819001833_ref26","doi-asserted-by":"publisher","DOI":"10.1021\/pr400096w"},{"key":"S0950268819001833_ref23","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01571-12"},{"key":"S0950268819001833_ref25","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.07085-11"},{"key":"S0950268819001833_ref27","unstructured":"People with Health Conditions. 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