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Data from 17 332 adult hospitalised patients admitted to Sir Charles Gairdner Hospital, Perth, Western Australia, with a respiratory illness between 2012 and 2015 were linked with data containing reverse transcription polymerase chain reaction results for respiratory viruses including A\/H1, A\/H3, influenza B, human metapneumovirus, respiratory syncytial virus and parainfluenza. Of these, 1753 (10.1%) had test results. Multivariable regression analyses were conducted to compare the viruses for clinical outcomes including ICU admission, ventilation, pneumonia, length of stay and death. Patients with A\/H1 were more likely to experience severe outcomes such as ICU admission (OR 2.5, 95% CI 1.2\u20135.5, <jats:italic>P<\/jats:italic> = 0.016), pneumonia (OR 3.0, 95% CI 1.6\u20135.7, <jats:italic>P<\/jats:italic> &lt; 0.001) and lower risk of discharge from hospital (indicating longer lengths of hospitalisation; HR 0.64 95% CI 0.47\u20130.88, <jats:italic>P<\/jats:italic> = 0.005), than patients with A\/H3. Patients with a non-influenza respiratory virus were less likely to experience severe clinical outcomes than patients with A\/H1, however, had similar likelihood when compared to patients with A\/H3. Patients hospitalised with A\/H1 had higher odds of severe outcomes than patients with A\/H3 or other respiratory viruses. Knowledge of circulating influenza strains is important for healthcare preparedness.<\/jats:p>","DOI":"10.1017\/s095026881900195x","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T01:19:28Z","timestamp":1574903968000},"source":"Crossref","is-referenced-by-count":26,"title":["Post-pandemic influenza A\/H1N1pdm09 is associated with more severe outcomes than A\/H3N2 and other respiratory viruses in adult hospitalisations"],"prefix":"10.1017","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4445-826X","authenticated-orcid":false,"given":"C. A.","family":"Minney-Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Selvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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