{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:33:52Z","timestamp":1790220832950,"version":"4.1.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"unspecified","delay-in-days":154,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>This study aimed to investigate the clinical characteristics and to analyse the epidemiological features of coronavirus disease 2019 (COVID-19) patients during convalescence. In this study, we enrolled 71 confirmed cases of COVID-19 who were discharged from hospital and transferred to isolation wards from 6 February to 26 March 2020. They were all employees of Zhongnan Hospital of Wuhan University or their family members of which three cases were &lt;18 years of age. Clinical data were collected and analysed statistically. Forty-one cases (41\/71, 57.7%) comprised medical faculty, young and middle-aged patients (aged \u2a7d60 years) accounted for 81.7% (58\/71). The average isolation time period for all adult patients was 13.8 \u00b1 6.1 days. During convalescence, RNA detection results of 35.2% patients (25\/71) turned from negative to positive. The longest RNA reversed phase time was 7 days. In all, 52.9% of adult patients (36\/68) had no obvious clinical symptoms, and the remaining ones had mild and non-specific clinical symptoms (e.g. cough, sputum, sore throat, disorders of the gastrointestinal tract etc.). Chest CT signs in 89.7% of adult patients (61\/68) gradually improved, and in the others, the lesions were eventually absorbed and improved after short-term repeated progression. The main chest CT manifestations of adult patients were normal, GGO or fibre streak shadow, and six patients (8.8%) had extrapulmonary manifestations, but there was no significant correlation with RNA detection results (<jats:italic>r<\/jats:italic> = \u22120.008, <jats:italic>P<\/jats:italic> &gt; 0.05). The drug treatment was mainly symptomatic support therapy, and antibiotics and antiviral drugs were ineffective. It is necessary to re-evaluate the isolation time and standard to terminate isolation for discharged COVID-19 patients.<\/jats:p>","DOI":"10.1017\/s0950268820001181","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T06:08:30Z","timestamp":1591164510000},"source":"Crossref","is-referenced-by-count":15,"title":["Epidemiological characteristics of COVID-19 patients in convalescence period"],"prefix":"10.1017","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-9249","authenticated-orcid":false,"given":"B. M.","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9717-3503","authenticated-orcid":false,"given":"Q. Q.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-8156","authenticated-orcid":false,"given":"L. Y.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1033-4720","authenticated-orcid":false,"given":"W.","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Y.","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"S0950268820001181_ref18","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200370"},{"key":"S0950268820001181_ref17","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.26.20042044"},{"key":"S0950268820001181_ref13","article-title":"Detectable SARS-CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia","author":"Zhang","journal-title":"Journal of Medical Virology"},{"key":"S0950268820001181_ref11","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.24.20042382"},{"key":"S0950268820001181_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"S0950268820001181_ref12","article-title":"Quantitative detection and viral load analysis of SARS-CoV-2 in infected patients","author":"Yu","journal-title":"Clinical Infectious Diseases"},{"key":"S0950268820001181_ref3","first-page":"1","article-title":"Diagnosis and treatment protocol for COVID-19 (trial version 7)","volume":"52","year":"2020","journal-title":"Jiangsu Journal of Traditional Chinese Medicine"},{"key":"S0950268820001181_ref2","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Wei-Jie","year":"2020","journal-title":"The New England Journal of Medicine"},{"key":"S0950268820001181_ref1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1729071"},{"key":"S0950268820001181_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"S0950268820001181_ref15","article-title":"Post-discharge surveillance and positive virus detection in two medical staff recovered from coronavirus disease 2019 (COVID-19), China, January to February 2020","volume":"25","author":"Xing","year":"2020","journal-title":"Euro Surveillance"},{"key":"S0950268820001181_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000774"},{"key":"S0950268820001181_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30083-2"},{"key":"S0950268820001181_ref6","article-title":"SARS-CoV-2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens","author":"Peng","journal-title":"Journal of Medical Virology"},{"key":"S0950268820001181_ref16","first-page":"270","article-title":"Follow-up testing of viral nucleic acid in discharged patients with moderate type of COVID-19","volume":"49","author":"Li","year":"2020","journal-title":"Journal of ZheJiang University (Medical Sciences)"},{"key":"S0950268820001181_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2783"},{"key":"S0950268820001181_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1732837"},{"key":"S0950268820001181_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2020.03.021"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268820001181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T09:46:55Z","timestamp":1591782415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268820001181\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":18,"alternative-id":["S0950268820001181"],"URL":"https:\/\/doi.org\/10.1017\/s0950268820001181","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e108"}}