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For most, HEV infection is acute, self-limiting and asymptomatic. However, patients that are immunocompromised, especially transplant patients, are at much higher risk for developing chronic infections, which can progress to cirrhosis and liver failure, along with overall increased mortality. Because of the rising trend of HEV serological prevalence among the global population, and the fact that TT-HEV infection can cause serious clinical consequences among those patients most at need for blood donation, the need for screening for TT-HEV has been gaining in prominence as an important public health concern for both developing and developed countries. In the review, we summarise evidence for and notable cases of TT-HEV infections, the various aspects of HEV screening protocols and recent trends in the implementation of TT-HEV broad-based blood screening programmes.<\/jats:p>","DOI":"10.1017\/s0950268820001429","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T03:53:50Z","timestamp":1593402830000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":57,"title":["Hepatitis E virus and blood transfusion safety"],"prefix":"10.1017","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-5969","authenticated-orcid":false,"given":"Hao","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"S0950268820001429_ref99","doi-asserted-by":"publisher","DOI":"10.4161\/hv.20042"},{"key":"S0950268820001429_ref97","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2017.22.16.30514"},{"key":"S0950268820001429_ref45","first-page":"502","article-title":"Seroprevalence of hepatitis E virus among blood donors in northern Italy (Sondrio, Lombardy) determined by three different assays","volume":"15","author":"Galli","year":"2017","journal-title":"Blood Transfusion"},{"key":"S0950268820001429_ref48","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14553"},{"key":"S0950268820001429_ref41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021150"},{"key":"S0950268820001429_ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-524348"},{"key":"S0950268820001429_ref46","first-page":"413","article-title":"A nationwide retrospective study on prevalence of hepatitis E virus infection in Italian blood donors","volume":"16","author":"Spada","year":"2018","journal-title":"Blood Transfusion"},{"key":"S0950268820001429_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.03.019"},{"key":"S0950268820001429_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61034-5"},{"key":"S0950268820001429_ref61","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-011-0210-5"},{"key":"S0950268820001429_ref34","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3078-9"},{"key":"S0950268820001429_ref86","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2018.23.35.1700616"},{"key":"S0950268820001429_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.06.013"},{"key":"S0950268820001429_ref43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119576"},{"key":"S0950268820001429_ref29","doi-asserted-by":"publisher","DOI":"10.3201\/eid2011.140516"},{"key":"S0950268820001429_ref62","first-page":"2009","article-title":"Prevalence of anti-hepatitis E virus antibodies in French blood donors","volume":"45","author":"Boutrouille","year":"2007","journal-title":"Journal of Medical Microbiology"},{"key":"S0950268820001429_ref26","first-page":"95","article-title":"Blood donor screening for hepatitis E virus in the European Union","volume":"46","author":"Boland","year":"2019","journal-title":"Transfusion Medicine and Hemotherapy Offizielles Organ der Deutschen Gesellschaft f\u00fcr Transfusionsmedizin und Immunh\u00e4matologie"},{"key":"S0950268820001429_ref44","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12929"},{"key":"S0950268820001429_ref40","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14531"},{"key":"S0950268820001429_ref47","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12326"},{"key":"S0950268820001429_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20215"},{"key":"S0950268820001429_ref39","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.4369"},{"key":"S0950268820001429_ref33","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12733"},{"key":"S0950268820001429_ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2000.7920072.x"},{"key":"S0950268820001429_ref32","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2013.18.31.20550"},{"key":"S0950268820001429_ref37","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13757"},{"key":"S0950268820001429_ref7","unstructured":"7. https:\/\/www.japantimes.co.jp\/news\/2018\/02\/01\/national\/world-firstwomans-death-linked-hepatitis-e-infection-blood-transfusion-japanesefacility\/. 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