{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:30:11Z","timestamp":1790440211035,"version":"4.1.0"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"unspecified","delay-in-days":208,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Biofire\u00ae Film Array Meningitis Encephalitis (FAME) panel can rapidly diagnose common aetiologies but its impact in Colombia is unknown. A retrospective study of adults with CNS infections in one tertiary hospital in Colombia. The cohort was divided into two time periods: before and after the implementation of the Biofire\u00ae FAME panel in May 2016. A total of 98 patients were enrolled, 52 and 46 were enrolled in the Standard of Care (SOC) group and in the FAME group, respectively. The most common comorbidity was human immunodeficiency virus infection (47.4%). The median time to a change in therapy was significantly shorter in the FAME group than in the SOC group (3\n                    <jats:italic>vs.<\/jats:italic>\n                    137.3 h,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). This difference was driven by the timing to appropriate therapy (2.1\n                    <jats:italic>vs.<\/jats:italic>\n                    195 h,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) by identifying viral aetiologies. Overall outcomes and length of stay were no different between both groups (\n                    <jats:italic>P<\/jats:italic>\n                    &gt; 0.2). The FAME panel detected six aetiologies that had negative cultures but missed identifying one patient with\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    . The introduction of the Biofire FAME panel in Colombia has facilitated the identification of viral pathogens and has significantly reduced the time to the adjustment of empirical antimicrobial therapy.\n                  <\/jats:p>","DOI":"10.1017\/s0950268820001648","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T03:45:49Z","timestamp":1595821549000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["Impact of the Film Array Meningitis\/Encephalitis panel in adults with meningitis and encephalitis in Colombia"],"prefix":"10.1017","volume":"148","author":[{"given":"Karen Melissa Ord\u00f3\u00f1ez","family":"D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Alexander Alzate","family":"Piedrah\u00edta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Felipe","family":"Su\u00e1rez Brochero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Orozco","family":"Granada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Marcela","family":"Bar\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Cort\u00e9s","family":"Bonilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-7089","authenticated-orcid":false,"given":"Rodrigo","family":"Hasbun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"S0950268820001648_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2018.05.008"},{"key":"S0950268820001648_ref16","doi-asserted-by":"publisher","DOI":"10.1177\/0897190017737697"},{"key":"S0950268820001648_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2015.11.017"},{"key":"S0950268820001648_ref12","first-page":"118","article-title":"Infectious meningitis\/encephalitis: evaluation of a rapid and fully automated multiplex PCR in the microbiological diagnostic workup","volume":"41","author":"Piccirilli","year":"2018","journal-title":"New Microbiology"},{"key":"S0950268820001648_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70050-6"},{"key":"S0950268820001648_ref3","doi-asserted-by":"publisher","DOI":"10.1086\/425368"},{"key":"S0950268820001648_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002442"},{"key":"S0950268820001648_ref6","doi-asserted-by":"publisher","DOI":"10.1086\/526530"},{"key":"S0950268820001648_ref9","first-page":"e01940","article-title":"One year in the life of a rapid syndromic panel for meningitis\/encephalitis: a pediatric tertiary care facility's experience","volume":"56","author":"Naccachea","year":"2018","journal-title":"Journal Clinical Microbiology"},{"key":"S0950268820001648_ref15","first-page":"212","article-title":"Epstein-Barr virus encephalitis in solid organ transplantation","volume":"40","author":"Lau","year":"2017","journal-title":"New Microbiology"},{"key":"S0950268820001648_ref2","doi-asserted-by":"publisher","DOI":"10.1086\/589747"},{"key":"S0950268820001648_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usx025"},{"key":"S0950268820001648_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70048-7"},{"key":"S0950268820001648_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01927-17"},{"key":"S0950268820001648_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00070-09"},{"key":"S0950268820001648_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3584-y"},{"key":"S0950268820001648_ref7","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00730-16"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268820001648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T02:09:34Z","timestamp":1597630174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268820001648\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":17,"alternative-id":["S0950268820001648"],"URL":"https:\/\/doi.org\/10.1017\/s0950268820001648","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2020. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e173"}}