{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:21:34Z","timestamp":1778127694441,"version":"3.51.4"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"unspecified","delay-in-days":296,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0950268820002587_sec_a1\">\n\t    <jats:title>Objectives<\/jats:title>\n\t    <jats:p>Cardiac injury is associated with poor prognosis of 2019 novel coronavirus disease 2019 (COVID-19), but the risk factors for cardiac injury have not been fully studied. In this study, we carried out a systematic analysis of clinical characteristics in COVID-19 patients to determine potential risk factors for cardiac injury complicated COVID-19 virus infection.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0950268820002587_sec_a2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>We systematically searched relevant literature published in Pubmed, Embase, Europe PMC, CNKI and other databases. All statistical analyses were performed using STATA 16.0.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0950268820002587_sec_a3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>We analysed 5726 confirmed cases from 17 studies. The results indicated that compared with non-cardiac-injured patients, patients with cardiac injury are older, with a greater proportion of male patients, with higher possibilities of existing comorbidities, with higher risks of clinical complications, need for mechanical ventilation, ICU transfer and mortality. Moreover, C-reactive protein, procalcitonin, D-dimer, NT-proBNP and blood creatinine in patients with cardiac injury are also higher while lymphocyte counts and platelet counts decreased. However, we fortuitously found that patients with cardiac injury did not present higher clinical specificity for chest distress (<jats:italic>P<\/jats:italic> = 0.304), chest pain (<jats:italic>P<\/jats:italic> = 0.334), palpitations (<jats:italic>P<\/jats:italic> = 0.793) and smoking (<jats:italic>P<\/jats:italic> = 0.234). Similarly, the risk of concomitant arrhythmia (<jats:italic>P<\/jats:italic> = 0.103) did not increase observably either.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0950268820002587_sec_a4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusion<\/jats:title>\n\t    <jats:p>Age, male gender and comorbidities are risk factors for cardiac injury complicated COVID-19 infection. Such patients are susceptible to complications and usually have abnormal results of laboratory tests, leading to poor outcomes. Contrary to common cardiac diseases, cardiac injury complicated COVID-19 infection did not significantly induce chest distress, chest pain, palpitations or arrhythmias. Our study indicates that early prevention should be applied to COVID-19 patients with cardiac injury to reduce adverse outcomes.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0950268820002587","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T03:15:38Z","timestamp":1603422938000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["Clinical characteristics of COVID-19 with cardiac injury: a systematic review and meta-analysis"],"prefix":"10.1017","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-7888","authenticated-orcid":false,"given":"Linwen","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4177-3320","authenticated-orcid":false,"given":"Shihui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-8068","authenticated-orcid":false,"given":"Jingjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"S0950268820002587_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.006"},{"key":"S0950268820002587_ref32","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"S0950268820002587_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2020.04.008"},{"key":"S0950268820002587_ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02466-1"},{"key":"S0950268820002587_ref16","article-title":"Radiographic findings and other predictors in adults with Covid-19","author":"Li","year":"2020","journal-title":"medRxiv"},{"key":"S0950268820002587_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1091"},{"key":"S0950268820002587_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"S0950268820002587_ref28","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4115"},{"key":"S0950268820002587_ref29","first-page":"E004","article-title":"[Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV]","volume":"48","author":"Peng","year":"2020","journal-title":"Zhonghua xin xue guan bing za zhi"},{"key":"S0950268820002587_ref13","article-title":"Risk factors associated with clinical outcomes in 323 COVID-19 patients in Wuhan, China","author":"Hu","year":"2020","journal-title":"Clinical Infectious Diseases"},{"key":"S0950268820002587_ref33","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-24567\/v1"},{"key":"S0950268820002587_ref30","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25767"},{"key":"S0950268820002587_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"S0950268820002587_ref12","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.3576807"},{"key":"S0950268820002587_ref39","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.41275"},{"key":"S0950268820002587_ref21","article-title":"Acute myocardial injury of patients with coronavirus disease 2019","author":"Xu","year":"2020","journal-title":"medRxiv"},{"key":"S0950268820002587_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1017"},{"key":"S0950268820002587_ref18","article-title":"Clinical features and outcomes of 2019 novel coronavirus-infected patients with cardiac injury","author":"Liu","year":"2020","journal-title":"medRxiv"},{"key":"S0950268820002587_ref26","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"S0950268820002587_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.0950"},{"key":"S0950268820002587_ref19","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317007"},{"key":"S0950268820002587_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06028-z"},{"key":"S0950268820002587_ref1","unstructured":"1. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e266"}}