{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:04:00Z","timestamp":1790528640879,"version":"4.1.0"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"unspecified","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Laboratory data increasingly suggest that<jats:italic>Salmonella<\/jats:italic>infection may contribute to colon cancer (CC) development. Here, we examined epidemiologically the potential risk of CC associated with salmonellosis in the human population. We conducted a population-based cohort study using four health registries in Denmark. Person-level demographic data of all residents were linked to laboratory-confirmed non-typhoidal salmonellosis and to CC diagnoses in 1994\u20132016. Hazard ratios (HRs) for CC (overall\/proximal\/distal) associated with reported salmonellosis were estimated using Cox proportional hazard models. Potential effects of serovar, age, sex, inflammatory bowel disease and follow-up time post-infection were also assessed. We found no increased risk of CC \u22651 year post-infection (HR 0.99; 95% confidence interval (CI) 0.88\u20131.13). When stratifying by serovar, there was a significantly increased risk of proximal CC \u22651 year post-infection with serovars other than Enteritidis and Typhimurium (HR 1.40; 95% CI 1.03\u20131.90). CC risk was significantly increased in the first year post-infection (HR 2.08; 95% CI 1.48\u20132.93). The association between salmonellosis and CC in the first year post-infection can be explained by increased stool testing around the time of CC diagnosis. The association between proximal CC and non-Enteritidis\/non-Typhimurium serovars is unclear and warrants further investigation. Overall, this study provides epidemiological evidence that notified<jats:italic>Salmonella<\/jats:italic>infections do not contribute significantly to CC risk in the studied population.<\/jats:p>","DOI":"10.1017\/s0950268821000285","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T02:06:51Z","timestamp":1612750011000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Association between<i>Salmonella<\/i>infection and colon cancer: a nationwide registry-based cohort study"],"prefix":"10.1017","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9197-9079","authenticated-orcid":false,"given":"Janneke W.","family":"Duijster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen V.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques J. C.","family":"Neefjes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Frisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lapo","family":"Mughini-Gras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Ethelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"S0950268821000285_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29418"},{"key":"S0950268821000285_ref23","unstructured":"23. National Institute for Public Health and the Environment (RIVM) (2018) Staat van Zo\u00f6nosen 2017. Available at http:\/\/www.rivm.nl\/bibliotheek\/rapporten\/2018-0112.pdf (Accessed 15 Nov 2019)."},{"key":"S0950268821000285_ref26","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2367"},{"key":"S0950268821000285_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21731"},{"key":"S0950268821000285_ref10","first-page":"e05500","article-title":"The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2017","volume":"16","year":"2018","journal-title":"EFSA Journal"},{"key":"S0950268821000285_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"S0950268821000285_ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03182"},{"key":"S0950268821000285_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf096"},{"key":"S0950268821000285_ref1","unstructured":"1. WHO. International Agency for Research on Cancer. Estimated number of new cases in 2018. Available at http:\/\/gco.iarc.fr\/ (Accessed 15 Nov 2019)."},{"key":"S0950268821000285_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.171"},{"key":"S0950268821000285_ref14","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317592"},{"key":"S0950268821000285_ref18","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810393562"},{"key":"S0950268821000285_ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189721"},{"key":"S0950268821000285_ref12","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2019.2705"},{"key":"S0950268821000285_ref13","unstructured":"13. Statistik om kr\u00e6ft i tyktarmen. Available at https:\/\/www.cancer.dk\/tyktarmskraeft-coloncancer\/statistik-tyktarmskraeft\/ (Accessed 15 Nov 2019)."},{"key":"S0950268821000285_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.05.002"},{"key":"S0950268821000285_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr188"},{"key":"S0950268821000285_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s101200200001"},{"key":"S0950268821000285_ref8","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-16-0124"},{"key":"S0950268821000285_ref22","unstructured":"22. Mangen, MJJ (2018) Disease burden of food-related pathogens in the Netherlands, 2017. RIVM Letter report 2018\u20130037. National Institute for Public Health and the Environment: Bilthoven. (Accessed 16 Oct 2020)."},{"key":"S0950268821000285_ref11","unstructured":"11. Anonymous (2016) Annual Report on Zoonoses in Denmark 2016, National Food Institute, Technical University of Denmark. Available at www.food.dtu.dk \u203a media \u203a Foedevareinstituttet \u203a Publikationer \u203a Pub-2017 (Accessed 15 Nov 2019)."},{"key":"S0950268821000285_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.223396"},{"key":"S0950268821000285_ref17","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"S0950268821000285_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh049"},{"key":"S0950268821000285_ref25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712345105"},{"key":"S0950268821000285_ref3","doi-asserted-by":"crossref","first-page":"e46632","DOI":"10.15252\/embr.201846632","article-title":"Bacterial infections and cancer","volume":"19","author":"Van Elsland","year":"2018","journal-title":"EMBO Reports"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268821000285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T15:55:53Z","timestamp":1697817353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268821000285\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":26,"alternative-id":["S0950268821000285"],"URL":"https:\/\/doi.org\/10.1017\/s0950268821000285","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2021. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e56"}}