{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:51:39Z","timestamp":1790729499964,"version":"4.1.0"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"unspecified","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and <jats:italic>Leptospira<\/jats:italic> spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans. We investigated the frequency of <jats:italic>Leptospira<\/jats:italic> spp. and hantavirus single and double infections in small mammals from 22 sites in Thuringia, central Germany, during 2017. TULV infections were detected at 18 of 22 sites (mean prevalence 13.8%, 93\/674). PUUV infections were detected at four of 22 sites (mean prevalence 1.5%, 7\/471), and respective PUUV sequences formed a novel phylogenetic clade, but DOBV infections were not detected at all. <jats:italic>Leptospira<\/jats:italic> infections were detected at 21 of 22 sites with the highest overall prevalence in field voles (<jats:italic>Microtus agrestis<\/jats:italic>) with 54.5% (6\/11) and common voles (<jats:italic>Microtus arvalis<\/jats:italic>) with 30.3% (205\/676). <jats:italic>Leptospira<\/jats:italic>\u2013hantavirus coinfections were found in 6.6% (44\/671) of common voles but only in two of 395 bank voles. TULV and <jats:italic>Leptospira<\/jats:italic> coinfection probability in common voles was driven by individual (age) and population-level factors. Coinfections seemed to be particularly associated with sites where <jats:italic>Leptospira<\/jats:italic> spp. prevalence exceeded 35%. Future investigations should evaluate public health consequences of this strong spatial clustering of coinfections.<\/jats:p>","DOI":"10.1017\/s0950268821000443","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T07:47:20Z","timestamp":1613980040000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":31,"title":["Hantavirus\u2013<i>Leptospira<\/i> coinfections in small mammals from central Germany"],"prefix":"10.1017","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8573-4588","authenticated-orcid":false,"given":"K.","family":"Jeske","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-6606","authenticated-orcid":false,"given":"J.","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-147X","authenticated-orcid":false,"given":"S.","family":"Drewes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-8224","authenticated-orcid":false,"given":"M.","family":"Pfeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-323X","authenticated-orcid":false,"given":"G.","family":"Heckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5620-1528","authenticated-orcid":false,"given":"R. 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