{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:56:01Z","timestamp":1780656961236,"version":"3.54.1"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Chinese National Science and Technology Major Project's 13th Five-Year Plan","award":["2017ZX10103010\u2013002"],"award-info":[{"award-number":["2017ZX10103010\u2013002"]}]},{"name":"the Chengdu Municipal Commission of Health and Family Planning","award":["2015149"],"award-info":[{"award-number":["2015149"]}]},{"name":"the National Key Research and Development Program of China","award":["2017YFC0907300"],"award-info":[{"award-number":["2017YFC0907300"]}]},{"name":"the National Key Research and Development Program of China","award":["2017YFC0907305"],"award-info":[{"award-number":["2017YFC0907305"]}]},{"name":"the Department of Science and Technology of Sichuan Province","award":["2019YJ0018"],"award-info":[{"award-number":["2019YJ0018"]}]},{"name":"the Chengdu Science and Technology Bureau","award":["2019-YF05-01247-SN"],"award-info":[{"award-number":["2019-YF05-01247-SN"]}]},{"name":"the Health and Family Planning Commission of Sichuan Province","award":["18PJ592"],"award-info":[{"award-number":["18PJ592"]}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>We investigated the drug resistance of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> isolates from patients with tuberculosis (TB) and HIV, and those diagnosed with only TB in Sichuan, China. TB isolates were obtained from January 2018 to December 2020 and subjected to drug susceptibility testing (DST) to 11 anti-TB drugs and to GeneXpert MTB\/RIF testing. The overall proportion of drug-resistant TB (DR-TB) isolates was 32.1% (<jats:italic>n<\/jats:italic> = 10 946). HIV testing was not universally available for outpatient TB cases, only 29.5% (3227\/10 946) cases had HIV testing results. The observed proportion of multidrug-resistant TB (MDR-TB) isolates was almost double than that of the national level, with approximately 1.5% and 0.1% of the isolates being extensively drug resistant and universally drug resistant, respectively. The proportions of resistant isolates were generally higher in 2018 and 2019 than in 2020. Furthermore, the sensitivities of GeneXpert during 2018\u20132020 demonstrated a downward trend (80.9, 95% confidence intervals (CI) 76.8\u201385.0; 80.2, 95% CI 76.4\u201384.1 and 75.4, 95% CI 70.7\u201380.2, respectively). Approximately 69.0% (7557\/10 946) of the TB cases with DST results were subjected to GeneXpert detection. Overall, the DR-TB status and the use of GeneXpert in Sichuan have improved, but DR-TB challenges remain. HIV testing for all TB cases is recommended.<\/jats:p>","DOI":"10.1017\/s0950268822000127","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T07:29:51Z","timestamp":1643354991000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["Drug resistance characteristics of <i>Mycobacterium tuberculosis<\/i> isolates obtained between 2018 and 2020 in Sichuan, China"],"prefix":"10.1017","volume":"150","author":[{"given":"Ruifeng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongliang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-7006","authenticated-orcid":false,"given":"Haojiang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"S0950268822000127_ref32","first-page":"1","article-title":"A preliminary study of antibodies and antigen kinetics in patients with COVID-19","volume":"Preprint","author":"Zhou","year":"2021","journal-title":"Research Square"},{"key":"S0950268822000127_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2012.10.009"},{"key":"S0950268822000127_ref13","unstructured":"13. 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