{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:57:06Z","timestamp":1747173426885,"version":"3.40.5"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"unspecified","delay-in-days":88,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Natural Foundation of China under Grant","award":["LGF19H180003"],"award-info":[{"award-number":["LGF19H180003"]}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>This study aimed to describe the clinical manifestations of adenovirus infections and identify potential risk factors for co-infection with chlamydia, viruses and bacteria in hospitalised children from Hangzhou, China. From January to December 2019, the characteristics of hospitalised children infected with adenovirus at Hangzhou Children's Hospital and Zhejiang Xiaoshan Hospital were collected. The clinical factors related to co-infection with chlamydia, viruses and bacteria were assessed using multivariate logistic regression analyses. A total of 5989 children were infected with adenovirus, of which 573 were hospitalised for adenovirus infection. The severity of adenovirus respiratory infection was categorised as follows: mild (bronchiolitis, 73.6%), moderate (bronchopneumonia, 17.6%) or severe (pneumonia, 8.8%). Of the 573 children who were hospitalised, 280 presented with co-infection of chlamydia, viruses or bacteria, while the remaining 293 had only adenovirus infection. Multivariate stepwise logistic regression analyses indicated that elevated ferritin was associated with an increased risk of chlamydia co-infection (odds ratio (OR) 6.50; 95% confidence interval (CI) 1.56\u201327.11; <jats:italic>P<\/jats:italic> = 0.010). However, increased white blood cell (WBC) count was associated with a reduced risk of viral co-infection (OR 0.84; 95% CI 0.75\u20130.95; <jats:italic>P<\/jats:italic> = 0.006). The study indicated that co-infection with chlamydia could be affected by elevated ferritin levels. WBC levels could affect viral co-infection in hospitalised children infected with adenovirus.<\/jats:p>","DOI":"10.1017\/s0950268822000565","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T05:59:25Z","timestamp":1648619965000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Identified risk factors for co-infection in hospitalised children infected with adenovirus in Hangzhou"],"prefix":"10.1017","volume":"150","author":[{"given":"Qun","family":"Lao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haipeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-3465","authenticated-orcid":false,"given":"Yuzhu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"S0950268822000565_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/50.5.279"},{"key":"S0950268822000565_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018584"},{"key":"S0950268822000565_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir531"},{"key":"S0950268822000565_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-014-0416-y"},{"key":"S0950268822000565_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.9.3963-3969.2004"},{"key":"S0950268822000565_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2127-z"},{"key":"S0950268822000565_ref10","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00116-13"},{"key":"S0950268822000565_ref7","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19178-0"},{"key":"S0950268822000565_ref16","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12191"},{"key":"S0950268822000565_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000451"},{"key":"S0950268822000565_ref15","doi-asserted-by":"publisher","DOI":"10.1039\/C3MT00347G"},{"key":"S0950268822000565_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.07.007"},{"key":"S0950268822000565_ref4","first-page":"2331","article-title":"Epidemiology and transmission characteristics of human adenovirus type 7 caused acute respiratory disease outbreak in military trainees in East China","volume":"8","author":"Cheng","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"S0950268822000565_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25333"},{"key":"S0950268822000565_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.04.015"},{"key":"S0950268822000565_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026596"},{"key":"S0950268822000565_ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-55"},{"key":"S0950268822000565_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21045"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268822000565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T08:12:32Z","timestamp":1650615152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268822000565\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":18,"alternative-id":["S0950268822000565"],"URL":"https:\/\/doi.org\/10.1017\/s0950268822000565","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"type":"print","value":"0950-2688"},{"type":"electronic","value":"1469-4409"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e80"}}