{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:38:00Z","timestamp":1769020680136,"version":"3.49.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"unspecified","delay-in-days":171,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>The study aimed to explore the relationship between eosinophils and the prognosis of varicella in adults. We retrospectively reviewed the medical records of patients who were hospitalised in The Fifth People's Hospital of Suzhou with a diagnosis of adult varicella during the period between 1 January 2012 and 31 December 2020. Of the 359 patients, 228 (63.51%) had eosinopenia. The proportion of patients with mild type disease was significantly lower in the eosinopenia group than that in the non-eosinopenia group (50.44% <jats:italic>vs.<\/jats:italic> 65.65%, <jats:italic>P<\/jats:italic> = 0.006). The proportion of the patients with common type disease was significantly higher in the eosinopenia group than that in the non-eosinopenia group (39.47% <jats:italic>vs.<\/jats:italic> 28.24%, <jats:italic>P<\/jats:italic> = 0.039). The proportion of the patients with severe type disease was higher in the eosinopenia group, although the difference did not reach statistical significance (10.09% <jats:italic>vs.<\/jats:italic> 6.11%, <jats:italic>P<\/jats:italic> = 0.243). The rates of high fever (47.81% <jats:italic>vs.<\/jats:italic> 32.82%, <jats:italic>P<\/jats:italic> = 0.008; relative risk (RR) 1.296, 95% confidence interval (CI) 1.091\u20131.540), headache (43.42% <jats:italic>vs.<\/jats:italic> 22.14%, <jats:italic>P<\/jats:italic> &lt; 0.001; RR 1.415, 95% CI 1.233\u20131.623), anorexia (53.51% <jats:italic>vs.<\/jats:italic> 35.88%, <jats:italic>P<\/jats:italic> = 0.001; RR 1.367, 95% CI 1.129\u20131.655) and complications (82.89% <jats:italic>vs.<\/jats:italic> 64.12%, <jats:italic>P<\/jats:italic> &lt; 0.001; RR 2.106, 95% CI 1.460\u20133.038) were also significantly higher in the eosinopenia group. Among the complications, the liver injury and skin infection were more serious in the eosinopenia group. The disease course was significantly longer in the eosinopenia group than that in the non-eosinopenia group (9.43 \u00b1 1.89 days <jats:italic>vs.<\/jats:italic> 8.73 \u00b1 1.25 days, <jats:italic>P<\/jats:italic> &lt; 0.001). The improvement rate of liver injury in the recovery period was lower in the eosinopenia group than that in the non-eosinopenia group (35.38% <jats:italic>vs.<\/jats:italic> 50%, <jats:italic>P<\/jats:italic> = 0.012). The study found that adult varicella patients with eosinopenia had a more serious condition, a higher morbidity of complications and a slower recovery. Blood eosinophils can be used as a new predictor of the severity of adult varicella.<\/jats:p>","DOI":"10.1017\/s095026882200111x","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T08:02:13Z","timestamp":1655798533000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Predictive role of blood eosinophils in adult varicella patients"],"prefix":"10.1017","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-7871","authenticated-orcid":false,"given":"Luxuan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiujuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"S095026882200111X_ref1","first-page":"95","article-title":"Varicella-zoster virus infection: natural history, clinical manifestations, immunity and 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characteristics of varicella in China, 2016\u20132019","volume":"26","author":"Dong","year":"2020","journal-title":"Vaccines and Immunization in China"},{"key":"S095026882200111X_ref24","first-page":"474","article-title":"Neutrophil-to-lymphocyte ratio, past, present and future perspectives","volume":"122","author":"Zahorec","year":"2021","journal-title":"Bratislavske Lekarske Listy"}],"container-title":["Epidemiology and 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e127"}}